il8及瘦素在硬皮病小鼠模型体内的表达及相关性研究-expression and correlation of il8 and leptin in scleroderma mouse model.docx

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il8及瘦素在硬皮病小鼠模型体内的表达及相关性研究-expression and correlation of il8 and leptin in scleroderma mouse model.docx

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il8及瘦素在硬皮病小鼠模型体内的表达及相关性研究-expression and correlation of il8 and leptin in scleroderma mouse model

本课题由国家自然科学基金NO资助完成独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于保密□ ，在年解密后适用本授权书。不保密□。（请在以上方框内打“√” ）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录缩略词中英文对照 ································································1 前言················································································2 中文摘要 ············································································4Abstract 5正文················································································7材料及方法 ·······································································7 结果 ··········································································· 13 讨论 ··········································································· 22 参考文献 ········································································ 25综述·············································································· 28附录·············································································· 42致谢·············································································· 43缩略词中英文对照缩略词IL-8英文全称Interluekin-8中文全称白细胞介素-8BLMbleomycin博莱霉素SScTGF-βsystemic sclerosistransforming growth factor-beta系统性硬皮病转化生长因子 βECMCTGFextracellular matrixconnective tissue growth factor细胞外基质结缔组织生长因子PDGFTNFplatelet-derived growth factortumor necrosis factor血小板衍生生长因子肿瘤坏死因子BALFPKbronchoalveolar lavage fluidprotein kinase支气管肺泡灌洗液蛋白激酶PLCMAPKphospholipase Cmitogen-activated protein kinase磷脂酶 C丝裂原激活蛋白激酶MCP-1CRPmonocyte chemoattractant protein-1C-reactive protein单核细胞趋化蛋白-1C 反应蛋白CTLTregscytotoxic T-lymphocyteregulatory T cells细胞毒性 T 淋巴细胞调节性 T 细胞PBMCERKperipheral blood mononuclear cellsextracellular signal–regulated kinase外周血单个核细胞细胞外信号调节激酶VCAM-1STAT-6vascular