结直肠癌病人血清中cea ca19-9 ln与预后关系的分析-analysis of the relationship between serum cea ca19 - 9 ln and prognosis in patients with colorectal cancer.docx

than A/B staging (P0.05). The positive rate of combination of CEA、LN related to thetumor whole typing was statistically significant (P0.05), and that of the combination of three biomarkers positive rate were related to the cancer different type and Dukes stages (P0.05).3：209 cases with integrity follow-up information were selected. The media follow-uptime is 25 months. One-year, three-year and five-year survival rate of the CRC patients were 92.3%, 72.7% and 53.8% respectively.4: The Log-rank test results showed that the colorectal cancer patients’ survival time was related to the following factors: tumor whole typing, differentiation degree, lymphatic metastasis, TNM classification, Dukes classification, post-operativechemotherapy, laboratory test results (including pre-operative serum level of CEA、CA19-9、the combination of CEA and CA19-9、 the combination of CEA and LN, the combination of CA19-9 and LN、the combination of above the three biomarkers ). 5：Post-operative chemotherapy, tumor Dukes’ staging and the level of three tumorbiomarkers in parallel were independent prognosis factors by COX regression test.Conclusion:1: This study only found that the combination of CEA、CA19-9 and LN positive rate related to CRC clinic/pathological factors were statistically significant. The relationship between single biomarker and clinic/pathological factors was not obvious in the study and further clinical or population research was needed to prove.2: High blood concentration of CEA、 CA19-9 and the combination of the threebiomarkers of colorectal cancer patients before resection pointed to poor prognosis, within which, the combination of the three biomarkers acted as independent prognosis factor. This study didn’t find out the positive association between LN and the cases’ prognosis.3: Dukes classification acted an important role in the colorectal cancer patients’ prognosis, which suggested that it should be taken full consideration of this factor. Key wordsCo