金属卟啉的合成与光学性质及其核磁增强性能的分析-synthesis and optical properties of metalloporphyrins and analysis of their nuclear magnetic enhancement properties.docxVIP

AbstractPhotodynamic therapy is one of the best example that optics applies in the biomedical field. The key of photodynamic therapy is photosensitizer. Porphyrin is the most commonly used as a photosensitizer. Porphyrin has three characteristics which are tumor cells targeting, fluorescence and photosensitivity. But it has a defect in the fluorescence diagnosis that it only could achieve the epidermal tissue cancer diagnosis because of the penetration depth limit of fluorescence. The cell destruction is also needs to paid enough attention to in the fluorescence diagnosis. Therefore, the purpose of this study was to take the paramagnetic metal into the porphyrin ring. On the one hand, because of the character of tumor cell targeting, this process made the metalloporphyrin as a magnetic resonance imaging contrast agent to diagnose the deep lying tumor. One the other hand, the special energy level structure of rare-earth metal and transition metal might change the optical property of porphyrin though the interaction between the energy levels, and then we could get the photosensitizer with specific properties. This paper systematically studied the synthesis, optical property, photosensitivity, energy level structure and the performance of nuclear magnetic enhancement of metalloporphyrin.The synthetic technology of metalloporphyrin was studied. The optimized synthetic technology was established which used imidazole as solvent, argon as shielding gas. The optimum technological condition was obtained This study used ultraviolet-visible absorption spectrum as the representation, and proposed the evaluation method of synthetic reaction process.The optical property of metalloporphyrins was studied. The fluorescence red shift phenomenon of gadolinium porphyrin happened. It was proved that the red shift fluorescence was due to the transition from porphyrin triplet energy level toground state. Time-resolved spectra results proved the assumption. The fluorescence peak position o