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老年人甲状腺功能异常的临床分析-clinical analysis of thyroid dysfunction in the elderly
thesepatientsandobservethedifferencesbetweendifferenttypesofthyroiddysfunction.Results256patients(27.1%)showedalterationsinthyroidfunctiontests.Euthyroidsicksyndrome(ESS)wasthederangementmorefrequentlyfound(n=170,18%).AfterexcludingESSpatients,86patients(9.1%)showedthyroiddysfunction:overthypothyroidism,8(0.9%);subclinicalhypothyroidism,53(5.6%);overthyperthyroidism,2(0.2%),andsubclinicalhyperthyroidism,20patients(2.1%).ESScancausebyseveralsystemicillnessandmedicines.ESSinacuteillnesswasmorethanthatinchronicillness.Hemoglobin,serumalbuminandbloodlipidswerelowerandserumcreatininehigherinESSpatientsthanthecontrolgroup.Hemoglobinwaslowerandcholesterolhigherinsubclinicalhypothyroidismpatientsthanthecontrolgroup.Surumalbuminwaslowerinsubclinicalhyperthyroidismpatientsthanthecontrolgroup.Thepresenceofalterationsinthyroidfunctiontestswaspositivelyassociatedwithmortality(p=0.000).SerumlevelsofT3andalbuminwerenegativelyrelatedtodeathduringhospitalisationConclusionTheprevalenceofalterationsinthyroidfunctiontestswashigh,ofwhichESSwasthemostone.ESSinacuteillnesswasmorethanthatinchronicillness.ESSwasassociatedwithseverepathogeneticconditionandpoorprognosis.Subclinicalthyroiddiseasesmayleadtoseveralclinicalandbiochemicaltestschangesofthepatients.ThereductionvaluesofserumT3andalbuminwerepowerfulpredictorsformortalityduringhospitalisationinelderlypatients.[KEYWORDS]agedpeople,euthyroidsicksyndrome,hypothyroidism,hypothyroidism,subclinicalthyroiddisease上海交通大学学位论文原创性声明本人郑重声明:所呈交的学位论文,是本人在导师的指导下,独立进行研究工作所取得的成果。除文中已经注明引用的内容外,本论文不包含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡献的个人和集体,均已在文中以明确方式标明。本人完全意识到本声明的法律结果由本人承担。学位论文作者签名:日期:年月日上海交通大学学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定,同意学校保留并向国家有关部门或机构送交论文的复印件和电子版,允许论文被查阅和借阅。本人授权上海交通大学可以将本学位论文的全部或部分内容编入有关数据库进行检索,可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□,在年解密后适用本授权书。本学位论文属于不保密□。(请在以上方框内打“√”)学位论文作者签名:指导教师签名:日期:年月日日期:年月日前言随着社会经济发展及人类保健意识的增强,人类寿命明显延长,许多国家已步入了老龄化社会。据WHO预计,2025年全世界60岁以上老龄人口总数将超过12亿,而我国人口老龄化速度已居世界首位。衰老与老年疾病已成为影响人类健康、人口素质和社会发展的突出问题。保持老年人健康,降低老年疾病带来的社会经济负担,是
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