力生长因子e肽促进骨愈合及含e肽生物活性材料的分析-analysis of force growth factor e peptide promoting bone healing and bioactive materials containing e peptide.docxVIP

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力生长因子e肽促进骨愈合及含e肽生物活性材料的分析-analysis of force growth factor e peptide promoting bone healing and bioactive materials containing e peptide.docx

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力生长因子e肽促进骨愈合及含e肽生物活性材料的分析-analysis of force growth factor e peptide promoting bone healing and bioactive materials containing e peptide

ABSTRACTMechano growth factor (MGF) is a novel growth factor from the alternative splicing of Insulin-like growth factor I (IGF-I) gene, which is expressed in response to the mechanic stimulation. Further studies have confirmed that MGF and its E peptide (MGF-Ct24E) could promote muscle hypertrophy, preserve cardiac muscle and repair the damage of nerves. Our previous studies concluded that MGF mRNA expressed highly in the cyclic stretched osteoblasts, suggested that MGF is a mechano-response molecule in bone and influences on the function of osteoblasts. these results indicated that MGF or MGF-Ct24E may play a major role in the process of bone healing. This research focus on the influence of MGF-Ct24E for fracture healing. Firstly, effects of the injected-MGF-Ct24E on radial fracture healing; Secondly, the preparation and property of the bioactive materials containing MGF-Ct24E. The main works and conclusions are included as follows:The effects of the injected-MGF-Ct24E on radial fracture healingThe animal models used in this study, with 5mm bone defect, were produced in the middle of the left radius in rabbits. After 3 days of the surgical operation, 0.2 mL MGF(0.36 and 0.72 g/L, control: PBS) was injected into the ends of fracture areas once per day for continuous 5 days. And then following detections were taken: ① After 4, 6, 8 weeks, X-ray photography was used to evaluate the healing of fracture; ② At 8th week,histological examinations were performed to observe the cell morphology. All results showed that MGF-Ct24E can accelerate fracture healing significantly in a rabbit model and shows a dose-dependent manner in a certain range.The preparation and property of the bioactive materials containing MGF-Ct24E.①The bioactive materials containing MGF-Ct24E was prepared in the ResearchCenter of Bioinspired Material Science ＆ Engineering;②GPC-MALLS was used to confirmed the influence of MGF-Ct24E introduction on molecular weight of PDLLA, which showed that the modifi