第一章-1 绪论（修改） 复杂分子合成化学 ---分析的设计与战略实践.pptVIP

复杂分子合成化学---分析设计与战略实践;有机合成是在一个真实的世界旁边创造着一个新的世界。 R. B. Woodward，1965;有机合成：挑战、奋斗、促进发展;SYNTHESIS;Importance of Synthesis;历史回顾（1828-1944）;历史回顾（二战之后）---Woodward 时代;历史回顾（1990-2000）;海洋毒素(1);海洋毒素(2);Industrial Important Compounds;理论分子与非天然复杂分子;有机分子工程学的历史是一个人类科学奋斗与追求的历史;合成设计：“大事化小，小事化了”！;Molecules Architectures;Trends in Synthetic Methodology;有机合成的今天与明天;Bio-manipulation;Combinatorial Chemistry Automation ----Library, Array, and Biochip;;分子多样性的理念;;;寡糖的自动化固相合成 Seeberger, et al. Science 2001, 291, 1523.;Curran, et al. Science 2001, 291, 1766.;工业需求的有机化学;ChiroTechnology;“通过科学发现创造繁荣”美国经济发展委员会（1998）;In Ariads RAPID technique, a therapeutic protein such as insulin (red) is linked to a protein (blue) that forms aggregates in a cells endoplasmic reticulum. Addition of a small-molecule drug (green) breaks up the aggregates, resulting in release of the therapeutic protein.;挑战无极限. 欲建大厦，先打地基!;参考文献;参考文献;参考文献;参考文献;参考文献;Synthesis Classifications;Linear Synthesis The target compound is made through a series of linear transformations.;2. convergent Synthesis (1) Individually prepared compounds are convergently brought together to make the target compound.;Convergent Synthesis (2) Triply Convergent Synthesis Three major components are brought together in a single step to make the target compound.;3. Divergent Synthesis For a class of compounds, it is advantageous to prepare a common intermediate and use this common intermediate to prepare all members of the class of agents. Examples: prostaglandins;Divergent Synthesis Prepare the structurally related products. Good strategy for the structure-activity studies. The basis of most combinational chemistry methods.;4. Total Synthesis ;5. Partial Synthesis (1);Partial Synthesis (2);6. Formal Synthesis vs. Total Synthesis;Formal Synthesis vs. Total Synthesis (2);7. Biomimetic (Total) Synthesis (1);Biomimetic (Total) Synthesis (2);Objectives