32P胶体介入治疗海绵状血管瘤临床价值.docVIP

32P胶体介入治疗海绵状血管瘤临床价值 　　【摘要】 目的 探索32P胶体联合地塞米松介入治疗海绵状血管瘤的临床价值。方法 海绵状血管瘤患者329例，根据血管瘤平面面积分为A、B、C 3组，行32P胶体联合地塞米松瘤内多点均匀注射介入治疗，观察临床疗效。结果 1次治愈率为55．0%，经2次治疗后总治愈率为80．29%，A、B、C 3组治愈率分别为94．4%、84．1%和63．9%，随血管瘤平面面积增大，治愈率逐渐下降(P32P胶体联合地塞米松介入治疗海绵状血管瘤，疗效确切、方法简便，早期治疗疗效更佳。? 　　【关键词】32P胶体；血管瘤；介入治疗；β射线 　　 　　The clinical value of colloidal 32P interventional radiotherapy on congenital hemangioma 　　 　　LIU SHI-juan，LIU CUI-e，LI Feng-qi，et al.Department of Nuclear Medicine，People’s Hospital Affiliated 　　Weifang Shandong Province 261041，China 　　? 　　【Abstract】 Objective To study the clinical value of colloidal 32P mixed with dexamethasone interventional radiotherapy on congenital hemangioma.Methods 329 patients with congenital hemangioma Medieal college were divided into 3 groups according to the area of hemangiomas.All the hemangiomas were injected with certain dose of colloidal 32P mixed with dexamethasone.Results The cure rate for all the patients was 55．0%after the first injection,and was 80．29%after the second injection.The cure rate were 94．4%,84．1%and 63．9%for group A,B and C respectively,It was decreased as the area of hemangiomas increased.The effective rates for group A,B and C were all 100%.Conclusion The interventional radiotherapy on congenital hemangiomas with colloidal 32P mixed with dexamethasone is effective and simple,especially for thehemangiomas in early time.? 　　【Key words】Colloidal 32P;Hemangioma;Interventional radiotherapy;Beta-ray 　　 　　血管瘤是婴幼儿最常见的良性肿瘤，起源于残余的胚胎成血管细胞，多见于婴儿出生时或出生后不久，其发病机制尚不完全清楚[1-2]。海绵状血管瘤一般不会自行消退，有甚者进行性发展，影响美容，甚至影响器官功能。1999年3月至2004年12月笔者用32P胶体联合地塞米松局部介入治疗海绵状血管瘤329例，取得良好效果，现分析报道如下。? 　　1 资料与方法? 　　1．1 临床资料 海绵状血管瘤患者329例，男100例，女229例，根据???史、临床检查、超声或穿刺确诊为海绵状血管瘤，排除动脉瘤、淋巴管瘤、动静脉瘘等。根据血管瘤平面面积分为A、B、C 3组，A组89例，血管瘤平面面积小于10 cm2 ；B组132例，血管瘤平面面积10~20 cm2；C组118例，血管瘤平面面积20 cm2，最大面积达66．7 cm2。? 　　329例海绵状血管瘤患者中，年龄2个月~1岁169例，1~10岁137例，11岁23例；头面部148例，四肢79例，胸背部102例；32P胶体介入治疗前未经任何处理290例，外科手术后复发14例，注射硬化剂无效22例，激光治疗未愈3例。? 　　1．2 治疗方法? 　　1．2．1 用药剂量 32P胶体(32磷酸铬胶体，Cr32PO4