单核细胞趋化蛋白-1在慢性肺心病患者中改变及其与心功能关系.docVIP

单核细胞趋化蛋白-1在慢性肺心病患者中改变及其与心功能关系 　　[摘要] 目的 探讨单核细胞趋化蛋白-1（MCP-1）在慢性肺心病患者中的改变及其与心功能的关系。 方法 采用酶联免疫吸附法测定30例慢性肺心病急性加重期患者入院时与出院前日缓解期血清MCP-1水平及30例健康体检者血清MCP-1含量。肺心病患者分两组，评价不同组血清MCP-1水平的差别。 结果 肺心病患者急性加重期与缓解期MCP-1水平分别为（31.19±5.87） pg/mL和（20.34±2.26） pg/mL，急性加重期高于缓解期，P＜0.01，且均高于正常对照组（19.33±1.06） pg/mL，P＜0.01，P＜0.05。心功能1组与心功能2组血清MCP-1水平分别为（36.25±3.36） pg/mL和（26.01±2.27） pg/mL，前者高于后者，P＜0.01，两者均高于对照组P＜0.01。 结论 MCP-1可能是参与慢性肺心病发生发展的重要免疫分子，可以促成慢性心衰发生，加速心功能失代偿的进展。 　　[关键词] 慢性肺心病；心力衰竭；单核细胞趋???蛋白-1；肺动脉高压 　　[中图分类号] R541.5 [文献标识码] B [文章编号] 1673-9701（2012）01-032-02 　　 　　The changes of monocyte chemoattractant protein-1 (MCP-1) in corpulmonale and the relationship between MCP-1 and heart function 　　LIANG Shuyan1 BAO Wenhua1 LIU Mingyuan2 YANG Guangyuan3 DONG Zhiwu4 LI Jianwei4 　　1.Department of Respiratory Medicine, the First Affiliated Hospital of Jiamusi University, Jiamusi 154002, China; 2.Department of Pharmacology, School of Basic Medicine, Jiamusi University, Jiamusi 154002, China; 3.Department of Circulation, the First Affiliated Hospital of Jiamusi University, Jiamusi 154002, China; 4.Laboratory Department of Jixi People’s Hospital in Heilongjiang Province, Jixi 158100, China 　　 　　[Abstract] Objective To investigate the changes of monocyte chemoattractant protein-1 (MCP-1) in corpulmonale and the relationship between MCP-1 and heart function. Methods Enzyme-linked immunoabsorbent assay (ELISA) was used to measured the content of MCP-1 in serum in 30 patients with acute exacerbation of corpulmonale and catabasis of corpulmonale, and in 30 healthy subjects. The patients with corpulmonale were divided into two groups equally according to heart function. Results The plasma MCP-1 level was significantly higher in patients with acute exacerbation of corpulmonale[(31.19±5.87) pg/mL], and catabasis of corpulmonale[(20.34±2.26) pg/mL], compared to that in the healthy subjects [(19.33±1.06) pg/mL] (P＜0.01, P＜0.05). And the plasma MCP-1 level of acute exacerbation of corpulonale patient