纳洛酮治疗阿维菌素中毒临床观察.docVIP

纳洛酮治疗阿维菌素中毒临床观察 　　[摘要] 目的 探讨纳洛酮治疗阿维菌素中毒的临床疗效。 方法 将32例农药阿维菌素中毒患者分为治疗组和对照组，对照组采用常规治疗，清水洗胃，吸氧、补液、利尿，保护肝、肾功能，抗生素及对症支持治疗，治疗组是在常规治疗的基础上加用纳洛酮0.8 mg静脉推注，然后以5%葡萄糖250 mL加纳洛酮1.2 mg持续静脉滴注（滴速2 mL/min）至患者神志转清，然后改为5%葡萄糖250 mL加纳洛酮1.6 mg静脉滴注，每日1次，连用3 d。两组根据治愈率、死亡率、平均清醒时间来判定疗效。 结果 治疗组总治愈率为93.75%，中毒昏迷患者平均清醒时间为（5.70±2.10）h；对照组治愈率为62.50%，中毒昏迷患者平均清醒时间为（12.44±6.07）h，两组比较差异有统计学意义（P ＜ 0.05）。 结论 纳络酮可提高抢救成功率及缩短平均清醒时间。 　　[关键词] 纳洛酮；阿维菌素；中毒；治疗 　　[中图分类号] R595.4 [文献标识码] A [文章编号] 1673-7210（2012）04（a）-0085-02 　　 　　Clinical observation of Naloxone in the treatment of avermectins poisoning 　　YANG Chunsheng WU Yiqiang HUANG Zhiang HUANG Chushan 　　The Second Peoples Hospital of Dongshan District in Jieyang City, Guangdong Province, Jieyang 522031, China 　　[Abstract] Objective To explore the clinical effect of Naloxone in the treatment of avermectin poisoning. Methods 32 cases of pesticide avermectin poisoning patients were divided into treatment group and control group. The control group was given routine treatment, water gastric lavage, oxygen, fluid replacement, diuresis, protecting liver, renal, antibiotic and symptomatic and supportive therapy. The treatment group was given the routine therapy plus Naloxone 0.8 mg intravenous injection, and then was given 5% Glucose 250 mL plus Naloxone (1.2 mg continuous intravenous infusion dripping speed 2 mL/min) to patients consciousness recovery, then changed to a 5% Glucose 250 mL plus Naloxone 1.6 mg infusion, once a day, for 3 days. According to the cure rate, mortality, average time, the curative effects of the two groups were judged. Results In the treatment group, the cure rate was 93.75%, the unconscious patients mean awake time was (5.70±2.10) hours; in the control group, the cure rate was 62.50%, the unconscious patients mean awake time was (12.44±6.07) hours, two groups had significant differences (P ＜ 0.05). Conclusion Naloxone can improve the success rate of rescue and shorten the average time. 　　[Key words] Naloxone; Avermectins; Poisoni