GP方案和吉非替尼单药一线治疗非小细胞肺癌疗效比较.pdfVIP

·18 · 肿瘤防治研究 2008 年第 35 卷增刊 GP 方 案 和 吉 非 替 尼 单 药 一 线 治 疗 非 小 细 胞 肺 癌 疗 效 比 较 梅 　齐 ,李 　睿 ,陈 　元 ,于世英 Compar ison of GP Regimen an d Gef it in ib in Fir st L in e Tr ea t men t of Advanced Non2small Cell L n g Ca ncer ME I Qi ,L I R i ,CH EN Y an , YU Shi2Ying D ep a rt m ent o f O ncol og y , Ton gj i H os pit a l , T on gj i Me di cal Col le ge , H a zho n g Un ivers it y o f Sci ence a n d Tec hnol o g y , W h a n 43 00 30 , Chi na Cor resp on di n g A t ho r : C H E N Y an , E2m ai l :chen y a n0 08 @16 3 . com Ab stract :Obj ect ive 　A nalyze constra st ively th e clinical efficac y a n d toxicity of GP ( Ge mcit a bine + Ci spla2 t in) regimen a nd sin gle ag ent Gefit inib in f ri st lin e t reatment of ⅢB ～ Ⅳst age non2small cell l n g cancer (N SCL C) . Meth ods 　Sixty case s with st ag e ⅢB ～ ⅣN SCL C p athologically p roved were enrolle d in thi s st dy . Oral Gef it inib 25 0mg d aily we re given to twen ty2six ca ses ; th e ot her t hirty2fo r cases w ere treat ed 2 2 w it h Ge mcita bine ( GEM ,125 0 mg/ m ) on d 1 an d d 8 an d Ci splat in (DD P ,7 5 mg/ m ) on d1. Every three w eek s( 2 1day s) as a cycle. The eff icacy an d adver se eff ec t s w ere eval at ed af t er two c ycle s o f treat me nt . Res lt s 　The overall resp onse rat e ( ORR) of sin gle ag ent Gef it inib gro p wa s 2 6 . 9 % ( 7/ 2 6) ,a nd th at of combined GP gro p w as 2 9 . 4 % ( 10/ 3 4) ; th ere i s no st at i stically significa nt diff eren ce ( P 0 . 05 ) . The clinical di sease control rat e of Gef it inib gro p w as 7 6 . 9 % ( 20/ 26 ) ,an d th at of GP gro p wa s 50 . 0 % ( 17/ 3 4) ; th e diff erence was significa nt ( P 0 . 05 ) . The main to xicities in cl ded t he alimen t ary t ract react ion a nd