rybp bmi1及lsd1蛋白在急性白血病中表达情况的研究-expression of rybp bmi 1 and ls d1 protein in acute leukemia.docxVIP

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rybp bmi1及lsd1蛋白在急性白血病中表达情况的研究-expression of rybp bmi 1 and ls d1 protein in acute leukemia.docx

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rybp bmi1及lsd1蛋白在急性白血病中表达情况的研究-expression of rybp bmi 1 and ls d1 protein in acute leukemia

RYBP、 RYBP、BMI1 及 LSD1 蛋白在急性白血病中表达情况的研究 5 5 BMI1 protein in AML and ALL patients was significantly higher than that in controls(P0.05), while the expression rate and level of BMI1 protein between AML and ALL had no statistical difference (P0.05). In AML,both RYBP and BMI1 were highly expressed.The expression rate and level between RYBP and BMI1 had no significant difference and the expression of RYBP was positively correlated with that of BMI1 in AML(r=0.640,P0.01). The expression of LSD1 protein was positive in leukemia cell line SHI-1、 HL-60 and K562 but negative in 17 controls. The LSD1 was expressed in 78.6% AL patients and 4.2% ALCR patients. The expression rate and level of LSD1 protein in AL was significantly higher than that in ALCR and controls (P0.05). The expression of LSD1 protein in AML and ALL patients was significantly higher than that in controls(P0.05), while the expression rate and level of LSD1 protein between AML and ALL had no statistical difference (P0.05). Conclusion: The expression of RYBP、BMI1 and LSD1 protein were low in patients without malignant hematological diseases,while that in leukemia cell line were significantly high.The expression level of RYBP、BMI1 and LSD1 protein high in newly diagnosed leukemia changed to low after complete remission.It is concluded that RYBP、BMI1 and LSD1 protein were over-expressed significantly in acute leukemia, suggesting that RYBP、BMI1 and LSD1 protein are associate with acute leukemia.They may be involved in the occurrence process of acute leukemia, thus they may be developed as biomarkers for acute leukemia. The expression of RYBP was positively correlated with that of BMI1 in AML. suggestting that in the pathogenesis of AML,RYBP may interact with BMI1 and PcG proteins may form unusually large protein complexes in the occureence process of acute leukemia. Keywords: Ring1 and YY1-binding protein(RYBP) ； B-cell specific moloney leukemia virusinsertion site 1 protein (BMI1)；Lysine specific demethyla