一体化便携式脑血氧检测系统和性能验证-integrated portable brain blood oxygen detection system and performance verification.docxVIP

摘要人脑血液动力学的大量研究带动其测量技术的提升，尤其是功能近红外光谱成 像系统（fNIRS）的研究，目前已经研制出应用于不同神经科学的设备。然而，国 际上已有的 fNIRS 系统大多由一套大型设备作为信号的驱动控制单元，外加一台 主机接收、显示和保存数据，此系统的缺点是设备庞大，成本高。为了实现 fNIRS 系统的便携式，无需计算机的直接介入，本实验室自主研发了一套 8 通道 fNIRS 系统。本系统以 ARM 为控制中心，代替以前计算机接收、显示和保存数据的功能， 串口屏作为用户界面显示参数配置和数据显示。本文主要针对系统的一体化设计 和为保证系统的性能所做的验证性实验做主要介绍。一体化设计主要是利用 ARM 控制串口显示屏，在 keil uVision4 开发平台进行 软件设计，通过 ARM 控制数据的传输，实现系统 5 大功能模块的设计。5 大功能 主要有区域拓扑图显示，通道曲线显示，参数配置，峰值检测，通道连接等，通 过串口或 USB 下载至系统，成功实现预期要求。本文从 phantom 模型实验和人体实验验证系统的性能，phantom 模型有效验证 了系统的稳定性，可重复性和可靠性。人体实验包括动手指任务和视觉刺激任务， 通过两种任务证明了系统的可行性，动手指任务中，分别从时间和空间维度分析 受试者动右手时，相应左脑运动区血氧含量的变化，结果显示左脑运动区氧合血 红蛋白变化量增加，还原血红蛋白的变化量减少，实验结果与已有的典型血流动 力学结果相一致；视觉刺激任务从左右眼的对比性测试中得出有效的血液动力学 结果。从上述可知，本实验室研制的系统具有良好的时间和空间动力学特征，证明了 本系统检测脑血氧含量的可行性，具有潜在的临床应用价值。关键词：一体化，功能近红外光谱成像，性能验证，模型实验ABSTRACTAbundant study on the hemodynamic response of a brain have brought quite a few advances in technologies measuring it.The most benefitted is the functional near infrared spectroscope (fNIRS) system.A variety of devices have been employed into a variety of neuroscience applications. However, up to now, fNIRS systems still rely on a host computer to receive, display and save data.The extra computer increases the cost of a fNIRS system.In order to extend the portability of fNIRS system, we propose a self-contained eight-channel fNIRS system. It eliminates the requirement for a computer. Instead, the system is centered by an ARM core, which takes charge in the role that a computer played before. A touch screen is integrated as an user interface to receive configurations and display data. The self-contained fNIRS system were eventually qualified by experiments on phantoms with distinct optical coefficients and subjects under different tasks. This article mainly discusses the design of the integration system and the reliability and effectiveness of the guarantee system for performance verification.The integration design is based on the application of serial interface screen, using keil to write programs.ARM controls da