个体化医的现状及其展望PPT演课件.pptVIP

* * Dysfunction of the ubiquitin-proteasome system – that normally serves as a clearing mechanism for abnormal proteins – is thought to be leading mechanism of cell death. Not all PD cases have Lewy bodies (especially some genetic cases with onset at early age; Fahn). * * All compared to 3/3 odds of particular genotypes vary with age the greqtest effect of apoe 4 is between 60-75 * * * * Genes are made up of DNA which is packaged on 46 chromosomes in the cell nucleus. The DNA of the human genome is estimated to contain some three billion nucleotide base pairs, made up of combinations of the