galectin3在脑膜瘤中表达及其临床意义-expression of galectin 3 in meningioma and its clinical significance.docx

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galectin3在脑膜瘤中表达及其临床意义-expression of galectin 3 in meningioma and its clinical significance.docx

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galectin3在脑膜瘤中表达及其临床意义-expression of galectin 3 in meningioma and its clinical significance

优秀毕业论文精品参考文献资料关键词脑膜瘤，Galectin-3，免疫组织化学宁夏医科大学硕士学位论文英文摘要宁夏医科大学硕士学位论文英文摘要ⅢⅢThe relationship between Galectin-3 expression in Meningioma and postoperative recurrenceABSTRACTObjective Meningiomas are common primary intracranial tumors. Most meningiomas are benign.Although they achieve a total resection, patients still have a recurrence. Through detecting expression of galectin -3 protein in normal brain tissue and in different levels’ meningiomas , we discuss the relations between galectin-3 and meningioma occurrence, recurrence, and provide a theoretical basis for meningioma diagnosis, treatment and prognosis.Methods Sixty patients were collected in neurosurgery of Affiliated Hospital of Ningxia Medical University from January 1998 to December 2004, who applied resection, pathologically confirmed as meningioma. Referring to the WHO gradingstandards[9], they were divided into benign meningioma group (WHOⅠlevel,36 cases) andatypical meningioma group (WHO Ⅱ level, 15 cases), malignant meningioma group (WHO Ⅲ level, 9 cases). And we also select 10 cases of normal brain tissues. Then we determine galectin-3 protein in normal brain tissues and pathological tissues by Immunohistochemicalmethod, observe differences of galectin-3 expression in different categories, and apply statistical analysis.Results The expression of galectin-3 protein in 10 cases of normal brain tissues aren’t positive, the expression of galectin-3 in atypical meningioma group was positive in 13 cases (87%), the expression of galectin-3 in atypical meningioma group was significantly higher than that in benign meningioma group (21 cases, 67%), the difference has statistics significance (Z =- 2.763, P 0.05); the expression of galectin-3 in malignant meningioma group meningioma group was positive in 9 cases (100%), the expression of galectin-3 inⅣⅣmalignant meningioma group meningioma group was significantly higher than that in benign meningioma group, the difference has statistics significance