α-亚麻酸多重乳液稳定性研究.docVIP

α-亚麻酸多重乳液稳定性研究 　　摘要：目的制备较为稳定的α-亚麻酸多重乳液。方法以多重乳液相对体积为衡量标准，用显微镜直接观察，分别探讨第一相中复合乳化剂亲水-亲油平衡（HLB）值以及复合乳化剂质量分数对α-亚麻酸W/O/W多重乳液稳定性的影响。用紫外分光光度法测定α-亚麻酸在多重乳液中的稳定性。结果第一相复合乳化剂HLB值为6.6，M（复合乳化剂）∶M（EL35）=5.6，乳化剂在多重乳液中的质量分数为9.9 %时，多重乳液相对体积最大，α-亚麻酸在多重乳液中的稳定性最好。结论制备了较稳定的α-亚麻酸多重乳液。 　　关键词：α-亚麻酸；多重乳液；稳定性 　　中图分类号：Ts218文献标识码：A文章编号：1672-979X(2009)01-0036-03 　　 　　Study on Stability of α-Linolenic Acid Multiple Emulsion 　　ZHANG Shi-xian1, 2, ZHONG Rui-qiang1, LIU Feng1, WANG Zheng-wu1 *, WANG Zhong-ni3 　　(1. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Chemistry Department; Zunyi Normal College; Zunyi 563002, China; 3. College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China) 　　Abstract：Objective To prepare stable α-linolenic acid multiple emulsion. Methods With relative volume percentages as measurement data, the effects of HLB value and concentration of complex emulsifier in the first phase on the stability of α-linolenic acid multiple emulsion (W/O/W) were examined by microscopic observation. The stability of α-linolenic acid in multiple emulsion was measured by ultraviolet spectrophotometry. Results The optimum conditions for complex emulsifier system were as follows: the HLB value of complex emulsifier in the first phase was 6.6; the ratio of M (complex emulsifier) to M (EL35) was 5.6; the mass fraction of emulsifiers in multiple emulsion was 9.9 %. Under the conditions mentioned above, the relative volume percentage of multiple emulsion was the biggest and the stability of α-linolenic acid was the best. Conclusion α-Linolenic acid multiple emulsion can be prepared with better stability. 　　Key words：α-linolenic acid; multiple emulsion; stability 　　 　　α-亚麻酸（α-LNA）为全顺式9, 12, 15-十八碳三烯酸，属ψ-3系列多不饱和脂肪酸，结构式见图1。药理实验表明，α-LNA在降血脂[1]、抗血栓[2]、抗炎、抗过敏[3]、预防心脑血管疾病[4,5]等方面都起着重要作用。人体内不能产生α-LNA，只能从外源食物中摄取。通过去饱和酶和碳链延长酶的催化作用，α-LNA可在体内代谢为二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）。因此，α-LNA是重要的保健食品原料。 　　图1α-LNA分子结构