心理干预在降低抗精神病药物致药源性肥胖中作用.docVIP

心理干预在降低抗精神病药物致药源性肥胖中作用 　　【摘要】 目的 探讨心理干预在抗精神病药物致药源性肥胖中的作用。方法 对160例首发精神分裂症住院患者随机分为研究组（80例，脱落5例）和对照组（80例，脱落11例），研究组采取在抗精神病药物治疗＋心理干预，对其进行有关肥胖知识的学习、合理饮食、加强锻炼、良好的生活规律和心情等干预综合治疗措施，对照组单独抗精神病药物治疗方法。对2组入院和出院及出院后6个月、12个月、18个月和24个月随访时的体重进行比较。结果 入院和出院时2组体重改变差异无显著性(P0.05)；随访结果比较，研究组（分别为66.95±10.51，67.05±10.51，67.09±10.55和68.19±10.79）和对照组(分别为72.48±9.96，73.01±9.89，73.36±10.07和75.00±9.18)，2组差异具有高度显著性(t=-3.23，-3.52，-3.64和-4.06；P 　　【关键词】 精神分裂症；抗精神病药物；肥胖；心理干预 　　 　　The Effect of the Psychological Intervention on Lossing Weight with Antipsychotic. Zhang Changjun, Fan Maolin, Cao Hong. Department of Psychiatry, Henan Provincial Mental Hospital, Xinxiang 453002, P.R.China 　　【Abstract】Objective To study the effect of the Psychological Intervention on lossing weight with antipsychotic. Methods Totally 160 first-episode inpatients who met the DSM-IV diagnosis criterion of schizophrenia were divided randomly into two groups: the experimental group (n=80, fall off 5 cases) received antipsychotic therapy with psycho-behavi oral (learning reasonable-food and drink, to strengthen training, good life-rule, good attitude of mind) therapy, and the control groups (n=80, fall off 11 cases) only received the antipsychotic for 10 weeks, the weight were assessed by before post-discharge and follow-up conducted for 6 months and 12 months and 18 months and 24 months respectively. Results The weight was no significant difference on admission and discharge between two groups(P0.05). After 6 months and 12 months and 18 months and 24 months, the weight in experimental group (66.95±10.51, 67.05±10.51, 67.09±10.55 and 68.19±10.79) were significantly lower than those in control group (72.48±9.96, 73.01±9.89, 73.36±10.07 and 75.00±9.18, P0.01~0.001). Conclusion The Psychological Intervention has significantly preventable effect on weight gain with antipsychotic. 　　【Key words】 Schizophrenia; Antipsychotic; Weight gain; The Psychological Intervention 　　 　　1 引 言 　　 　　抗精神病药物（AP）所致体重增加乃至肥胖的发生率超过50%[1,2]。而肥胖不仅影