具有非线性免疫反应及感染时滞的htlv-i型病毒渐近型分析-asymptotic analysis of htlv - i virus with nonlinear immune response and infection delay.docxVIP

AbstractHTLV-I Virus maily infectes CD4+T cell througn the transmission way of cell-to-cell contact. The HTLV-I-specific CD8+ cytotoxic T lymphocytes (CTL) play significantly important roles of killing the infected nuclear and reducing the number of proviral loads, but the high levels of CTL and their cytotoxicity are the chief contributor to the development of HAM/TSP.Horacio Gómez-Acevedo et al proposed an ODE model for HTLV-I intection of CD4+T cells that incorporated CTL response. First of all, in order to describe the time between from a uninfected cell contacts infected cells to that cell is infected by HTLV-I virus and this period of time between from monitoring to infected cells to producing an CTL immune response, based on the Horacio Gómez-Acevedo et al,this paper established a mathematical model with the time delayτ1of infection andthe time delayτ 2of CTL immunity. Secondly, In this paper, there are also twothreshold parametersR0andR1 , the basic reproduction number for viralpersistence and CTL response, respectively. Further more, the existence and stability of the equilibrium points are discussed. Our mathematical analysis shows that, theinfection-free equilibriumP0 is globally asymptotically stable, and the eliminationof disease whenR1 ≤ 1 ; The asymptomatic carriers equilibrium is globallyasymptotically stable, and the infection becomes long-term and without lasting CTLresponse WhenR1 1 R0 . During the study the dynamic behavior of HAM/TSPequilibrium, we divided into two kinds of cases, HAM/TSP equilibrium is globally attractive; The parameters conditions to ensure the stability of the HAM/TSPequilibrium for the time delay τ 2are given whenτ1 0 ，τ 2 = 0 . We also discuss theinfluences of the time delay τ1of infection and the time delay τ 2of CTLimmunity to the stability of model (3-2) at the HAM/TSP equilibrium. Finally, the conclusions above are proved by using numerical simulation.Keywords: HTLV-I