The Effect of Voluntary Exercise on Neurogenesis in Senescent 自愿运动对衰老的影响神经发生.pptVIP

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2018-06-06 发布于浙江
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The Effect of Voluntary Exercise on Neurogenesis in Senescent 自愿运动对衰老的影响神经发生.ppt

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The Effect of Voluntary Exercise on Neurogenesis in Senescent 自愿运动对衰老的影响神经发生

The Effect of Voluntary Exercise on Neurogenesis in Senescent Accelerated Mice Ashley M. Fortress Faculty Mentor: Kevin C.H. Pang, Bowling Green State University Department of Psychology and the J.P. Scott Center for Neuroscience, Mind, and Behavior What is neurogenesis and why do we care? Definition: Neurogenesis is the birth of new neurons Many brain disorders show a loss in hippocampal cell volume, for example: Depression and Alzheimer’s Disease (AD). Exercise and environmental enrichment have been demonstrated to increase cell proliferation and survival in the dentate gyrus of the hippocampcal formation of rats (VanPraag, Kempermann Gage, 1999). This is the same brain area where cell volume is compromised. The amount of proliferation and survival seen in aged rats is significantly less than what is seen in young rats (Churchill et al 2002). Acetylcholine in forebrain increases neurogenesis; 192 IgG Saporin lesioning cholinergic activity in forebrain decreases neurogenesis and impairs spatial memory (Mohapel, Leanza, Kokaia, Lindvall, 2005). Neurogenesis has psychiatric implications as well: chronically administering SSRIs increases the amount of neurogenesis (Malberg Schecter, 2005). The Hippocampus: A closer view Results/Conclusions Age effect: isolated tissue samples show a decline in neurogenesis across the lifespan (consistent with other literature). Exercise effect: exercise greatly enhanced neurogenesis for the young animals, exercise may have had an effect for the middle aged animals, but remains inconclusive at this point. Neurogenesis was absent in the aged animals regardless of condition. The Future of Neurogenesis Supplementing the Exercise with Enriched environment Continued work with not only proliferation, but survival of new ‘neurons’ Double labeling with NeuN and GFAP BDNF infusions Exercise starting at a young age and sacrificing at middle aged period Administering SSRIs Possible Cholinergic Lesions * * What Does N