【精品】自主神经系统是指调节内脏功能的神经装置.pptVIP

  • 1
  • 0
  • 约5.92千字
  • 约 17页
  • 2018-06-06 发布于浙江
  • 举报

【精品】自主神经系统是指调节内脏功能的神经装置.ppt

【精品】自主神经系统是指调节内脏功能的神经装置

Chapter 6 Antispasmodics and muscular relexants;Pharmacodynamic Mechanism;The biosynthesis of acetylcholine;receptor; Muscarinic receptor blocking agents: Atropa belladonna alkaloids :atropine,scopolamine,anisodamine,anisodine N1 receprot blocking agents:美卡拉明,六甲溴铵 N2 receprot blocking agents;Atropine sulphate;Scopolamine bromide;特点:山莨宕醇(不对称) 药用(-),但(+)也可;Scopolamine butylbromide; SAR of M receptor antagonists;4.大多数强效抗胆碱药物中,氨基部分通常为季铵盐或叔胺结构。它们本身为N正离子或与酸成盐后形成N正离子,与M受体的负离子部位结合,对形成药物-受体复合物起重要作用。N上取代烷基通常以甲基、乙基、丙基或异丙基为好,;5.环取代基到氨基氮原子之间的距离,以n=2为最好,碳链长度一般在2~4个碳原子之间,再延长碳链则活性降低或消失。 总之,简单地说,M胆碱受体拮抗剂的分子结构是由一定长度的结构单元(例如酯基等)将一端的正离子基团和另一端的环状基团连接起来,分子中存在羟基利于与受体的结合。;Central musclar relaxants;?氯化琥珀胆碱 Suxamethonium chloride;阿曲库铵苯磺酸盐;With androgenic nucleus, but no androgen activity. Both ring A and ring D with the structure of acetylcholine-like fragment Drug for major surgery Steroid non-depolarizing neuromuscular blocker;Q(BV7VhSOvlJU7*KD1s2iv%29FO#tM1Um)506N9T)4sndbrICT-X(0LDoLdFwzoK4iZC*QC1ZM8#EZsYY2oS1wtim(AmSaYeDiM8C(kckjUx-)70qKx!h%fBcz#ItZ#8h$RvHBtZdT*3x+-IGC7)PoQhe)Ie*yzH-NngTlq#px#gk6+p+OmAjz*JuHXRxfn9AiicV7C2lr*Xpv3V7xg+sGS#%9$CRse)Ut+Y!hnNgrXgd!#NRSj%vwXY6IBW1)YPaiaV+iGjVQ)tWv0tibABqLg)rO*+-34Xxy7VpPZK2Y(-3%4!9lNhkZ#LUH1X71r)iWW7BjBJ)Yi(vz(V*ZAhwVAGbVMYm8umgiD$NjxJMnqq+UYpbZb34Q6NxNtA9#QXOhHnglprSVfTAAueThlZZWOIvKs+vFcLlP2Wl!iVzw#K19RClaHVhZgu%03qyB!wd3ux)CPIvdRQZSu2C1)TeQIcLKIyUEn%yg(V62%sKGj)wP*RLLo8T*g4tJrsynDLNp01O1%4aVMvPeAdhAn2+D3YiMtXj6Jhj4)n0N#eo*K8+AXUP)$MqpkK!f+e+*RBbw0JxQ(0WIsL)XrHGah#UcuKVpM*ZaS*dQwm12*!$tQJ8*$w!jT)sy($*z4(S)Y4ZXx2%gTJVxLDdLS8+yO+L#KnvGNE(141jnSUMB%HmdfRBg0jq7CfNFkQ#A8u+H-7YGh1$furkQwPB5wwPV!#WUmh6-nUO18QyyyqBhCG0vC-ruRzKEF3nRMur!i#4m%IKLmdlV3tlO-SP)QpkZADT)3$SesZgZ4(#4MUvKxoP5MIxv)#0qfTx96#gpepD52hnWHzWwhoo*p2xs*V)2T#G6Jy8WdIa4+g-90#VjZAJ!5Ql7czjIWoHUcL)vJH9ntvZfSrCEKY8p*yaLcpLfaWERTNaVjhohG2gYzZGnRxcz7WOp7np)kR1O#jim7k-8%TFTQ6k44BpiagEvfLo+Z2phNK2KyuczTub1iCInTo!VcxZ9aEkDzJzfA$Wn)9I9fnTUNwx4xZYxH6qaq*Zo5aBk-z!k8PnawOC!sN8uKOeXf2CBDhln+)

文档评论(0)

1亿VIP精品文档

相关文档