Oxidative stress mediates hippocampal neuron death in rats ：氧化应激介导的大鼠海马神经元死亡.ppt

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Oxidative stress mediates hippocampal neuron death in rats ：氧化应激介导的大鼠海马神经元死亡.ppt

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Oxidative stress mediates hippocampal neuron death in rats ：氧化应激介导的大鼠海马神经元死亡

* Oxidative stress mediates hippocampal neuron death in rats after lithium–pilocarpine-induced status epilepticus Jinzhi Liu, Aihua Wang, Lili Li, Yanfei Huang, Ping Xue and Aijun Hao Seizure: European Journal of Epilepsy Volume 19, Issue 3, Pages 165-172 (April 2010) DOI: 10.1016/j.seizure.2010.01.010 Copyright ? 2010 British Epilepsy Association Terms and Conditions Fig. 1 Source: Seizure: European Journal of Epilepsy 2010; 19:165-172 (DOI:10.1016/j.seizure.2010.01.010 ) Copyright ? 2010 British Epilepsy Association Terms and Conditions Fig. 2 Source: Seizure: European Journal of Epilepsy 2010; 19:165-172 (DOI:10.1016/j.seizure.2010.01.010 ) Copyright ? 2010 British Epilepsy Association Terms and Conditions Fig. 3 Source: Seizure: European Journal of Epilepsy 2010; 19:165-172 (DOI:10.1016/j.seizure.2010.01.010 ) Copyright ? 2010 British Epilepsy Association Terms and Conditions Fig. 4 Source: Seizure: European Journal of Epilepsy 2010; 19:165-172 (DOI:10.1016/j.seizure.2010.01.010 ) Copyright ? 2010 British Epilepsy Association Terms and Conditions Fig. 5 Source: Seizure: European Journal of Epilepsy 2010; 19:165-172 (DOI:10.1016/j.seizure.2010.01.010 ) Copyright ? 2010 British Epilepsy Association Terms and Conditions High power (40×) photomicrographs showing HE staining with hematoxylin and eosin of the hippocampal CA3 pyramidal neurons at 6h and 7 days rats after LPCSE. (A) The changes of the hippocampal CA3 pyramidal neurons at 6h and 7 days in rats after SE with or without FK506. Bar=20μm. (A′) The number of surviving cells after SE. Compared with control rats, the surviving cells of rats of SE group showed decrease significantly. FK506 could keep from cells damage. Bars indicate mean±SD. *P0.05 vs. control. #P0.05 vs. pilo Changes of NO level, cNOS and iNOS activity after LPCSE. (A) Changes of NO level after SE; (A′ and A″) the effects of FK506 on NO level at 6h and 7 days after SE. (B) Changes of cNOS activity after SE; (B′) the effects of FK506 on cNOS act