运动中活性氧与抗氧化剂补充内稳态研究述评.docVIP

运动中活性氧与抗氧化剂补充内稳态研究述评 　　摘要:有氧代谢不可避免地产生活性氧(reactive oxygen species,ROS)。尽管过多的ROS具有毒性作用,但一定的ROS却在细胞信号转导和抗氧化酶基因表达上起着重要的作用。运动训练能建立和维持氧化-抗氧化内稳态(oxidant-antioxidant homeostasis,OAH)。OAH可以将ROS维持在一定的水平。OAH可以抵抗的ROS涨落有一定的范围(OAH-specific ROS level zone,oROZ),其最大值和最小值分别记为maxROZ和minROZ。将刚能引起氧化应激的ROS称为应激ROS水平(stressful ROS level,sROS)。如果ROS水平经常低于minROZ,OAH就会退化。当ROS水平超过maxROZ达到sROS时,就可以打破现有OAH,建立抗氧化能力更强的新OAH。如果ROS水平引起细胞凋亡或损伤,补充外源性抗氧化剂是有益的。如果将ROS水平降低到minROZ之下,就会影响OAH的维持,外源性抗氧化剂的补充是有害的。如果将sROS降低到oROZ之中,就会影响新的OAH的建立,外源性抗氧化剂的补充是无益的。 　　关键词:运动生物化学;活性氧;抗氧化剂;氧化应激;内稳态;综述 　　中图分类号:G804.2文献标识码:A文章编号:1006-7116(2009)11-0100-05 　　 　　Review of researches on active oxygen and antioxidant supplementation during exercising from the perspective of homeostasis 　　ZHANG Jing-hong1,LU Jian1,CHEN Cai-zhen1,LIU Cheng-yi2 　　(1.School of Physical Education Health,East China Normal University,Shanghai 200241,China; 　　2.Laboratory of Laser Sports Medicine,South China Normal University,Guangzhou 510006,China) 　　 　　Abstract: It is inevitable for aerobic metabolism to produce active oxygen (OA). Although excessive OA is toxic, a certain level of OA plays an important role in cell signal transduction and antioxidase gene expression. Sports training can establish and maintain a homeostasis between oxidation and antioxidation (HO-A), which can maintain OA to a certain level. There is a certain range (RH) in which the HO-A is able to resist the fluctuation of the OA level. The maximum value and minimum value of RH are denoted as maxRH and minRH respectively. The OA level that is just high enough to cause an oxidation reaction is called the reactive active oxygen (ROA) level. If the OA level is frequently lower than the minRH, the HO-A will degenerate. When the OA level exceeds the maxRH to reach the ROA level, the existing HO-A can be broken, and a more powerful new HO-A will be established. If the OA level causes the decease or damage of cells, supplementing an exogenous antioxidant is helpful. If the OA