青少年体重指数与血清瘦素等生化指标之间关系.docVIP

青少年体重指数与血清瘦素等生化指标之间关系 　　【摘要】 目的 研究青少年肥胖程度与血清瘦素、 胰岛素、血糖及血脂等的相关性，为成年期疾病的早期预防提供相关依据 。方法 随机选取83名中学生，其中肥胖学生47名，正常学生36名。测 定血清瘦素、胰岛素、血糖及血脂等指标，计算胰岛素抵抗指数（HOMA-IR）。结果除血糖外，血清各项检测指标肥胖组均高于正常组(P值均＜0.05）；83名 中学生BMI和血清瘦素及其他各项指标均呈显著正相关(P值均＜0.05）。女生只有三酰 甘油、胰岛素和胰岛 素抵抗指数与瘦素水平显著正相关。结论 BMI对血清瘦素水平影响最明 显，对糖、脂代谢的影响相对较小；肥胖组存在明显的高瘦素血症（瘦素抵抗）、高胰岛素 血症、胰岛素抵抗（IR）和轻微的脂代谢异常。 　　【关键词】 人体质量指数；瘦素；血液化学分析；青少年 　　【中图分类号】 R 179 R 589.2 【文献标识码】 A 【文章编号】 1000-98 17(2007)08-0723-02 　　Relationship Between BMI and Serum Leptin and Other Biochemical Indicesin Adolescents/ GUO Jun-yan, ZHENG Lin-lin, MAN Yong-xian. Chemical C ollege of Eastern Liaoning University, Dandong(118000), Liaoning Province, China 　　【Abstract】 ObjectiveTo investigate the relationship between BMI and serum leptin,insulin, serum glucose and lipid in adolescence, and to provide evidence for th e early prevention of adulthood diseases. MethodsEighty-thre e students were cho sen randomly, 47 were obese and the other 36 were normal. Their fasting serum le vels of leptin insulin, glucose, total cholesterol (TC), triglyceride(TG) and lo w density lipoprotein(LDL) were analyzed, and homeostasis model assessment of in sulin resistance(HOMA-IR) were calculated. ResultsThe indicesin obese adolesce nts were higher than the normal except glucose(P＜0.05). BMI and serum lepti n wer e positively correlated with serum indices but glucose(P＜0.05). In female o besestudents, only TG, insulin and HOMA-IR were positively correlated with serum lep tin.ConclusionBMI influences serum leptin significantly andslightly influenc es glucose and lipid metabolism. High prevalence of hyperleptinemia, hyperinsuli nism, insulin resistant(IR) and slightly abnormity in lipid metabolism. 　　【Key words】 Body mass index;Leptin;Blood chemical analysis;Ad olescent 　　 　　儿童和青少年肥胖的发病率近???来呈逐年上升的趋势。资料表明，其危害不仅在于影响 营养物质代谢，引起发育延缓和内分泌功能异常，而且还与成年期肥胖、糖尿病、高脂血症 、高血压、冠心病等的发生密切相关［1-3］。笔者通过对肥胖与正常组青少年的BMI 、血清瘦素、胰岛素、血糖、血脂的测定及分析，探讨青少年肥胖与瘦素敏感性、胰岛素敏 感性、血糖及血脂的关系，以了解肥胖青少年发生上述相关疾病的危险性。 　　 　　1 对象