应用科学讲座抗生素（英文PPT）.ppt

* Which of the following is NOT considered as part of the criteria for SIRS? RR 20/min Heart rate 60 Temp 360C or 380C PaCO2 32mmHg SIRS Systemic inflammatory response syndrome 2 or more of the following criteria: Temperature 36 0C or 38 0C HR 90 PaCO2 32mmHg RR 20 WBC 12.0? 4.0, or 10% immature (band) forms (? Include change in mental state / hyperglycaemia in absence of diabetes) Associated definitions Sepsis Documented infection together with 2 or more SIRS criteria Severe sepsis Sepsis associated with organ dysfunction Septic shock Sepsis with refractory hypotension or hypoperfusion abnormalities in spite of adequate fluid resuscitation Rationale Ideally narrow spectrum Consider likely organisms Start broad spectrum then narrow with culture results Other considerations Route Length of course Appropriate dose Renal failure Information / guidelines BNF Local guidelines Microbiologist Summary All Figures were produced using Servier Medical Art - Classification of bacteria Gram Negative Vs. Gram Positive Discussed the broad mechanisms of action of antibiotics Consider important features of some of the main classes of antibiotic Discussed penicillin allergy Defined SIRS, sepsis septic shock Discussed prescribing strategies where to access help / information Slide 001 Slide 003 Applied Sciences Lecture Course Antibiotics Dr Cathy Armstrong SpR In Anaesthesia Clinical Fellow in Undergraduate Medical Education Manchester Royal Infirmary March 2011 Applied Sciences Lecture Course Objectives Understand the classification of bacteria Discuss the broad mechanisms of action of antibiotics Consider important features of the main classes of antibiotic Understand penicillin allergy Understand the definitions of SIRS, sepsis septic shock Be aware of some prescribing strategies where to access help / information Definitions Antibiotic Molecules that kills or stop the growth of microorganisms Bactericidal Antibiotics that kill bacteria Bacteriosta