荣胃阻癌方治疗慢性萎缩性胃炎癌前病变临床观察.docVIP

荣胃阻癌方治疗慢性萎缩性胃炎癌前病变的临床观察【摘要】? 　　目的 观察荣胃阻癌方治疗慢性萎缩性胃炎(CAG)癌前病变的临床疗效。方法 将112例CAG癌前病变患者随机分为2组，治疗组64例予荣胃阻癌方，每次250 g，每日2次口服。对照组48例予胃复春片，每次4片，每日3次口服。2组均12周为1个疗程，共治疗2个疗程。观察2组临床疗效及症状、胃镜及病理疗效。结果 治疗组总有效率95.31%，对照组总有效率81.25%，2组比较差异有统计学意义(P0.05)；治疗组症状、胃镜及病理疗效均优于对照组(P0.05)。结论 荣胃阻癌方治疗CAG癌前病变疗效确切。 【关键词】? 癌前状态 慢性病 胃炎 萎缩性 并发症 胃肿瘤 汤剂 中药疗法 ??? 【Abstract】? Objective? To study the effect of Rongweizuai compound (RC) on gastric precancerous lesion (GPL) in patients suffering from chronic atrophic gastritis (CAG) differentiated as spleen deficiency with liver stagnation and blood stasis in TCM syndrome differentiation. Methods? One hundred and twelve patients fitting to the admittance criteria were randomly divided into two groups, sixty four patients were treated with RC as the treatment group and forty eight cases were treated with Weifuchun as the control group, all cases were treated for 24 weeks. Results? The curative effects of symptom, gastroscopy and pathologic changes in the treatment group were significantly improved compared with those in the control group (P0.05). The effect of anti-Helicobacter pylori between the two groups had no significant difference (P0.05).Conclusion? RC is a good effective drug for GPL. 　　【Key words】? Gastric precancerous lesion; Chronic disease; Atrophic gastritis; Complication; Gastric tumor; Decoction 　　慢性萎缩性胃炎(chronic atrophic gastritis，CAG)是以胃黏膜上皮和腺体萎缩、黏膜变薄、黏膜肌层增厚及伴有肠上皮化生(IM)、不典型增生(ATP)为特征的慢性疾病［1］。2007-03—2007-12，我们采用荣胃阻癌方治疗CAG癌前病变64例，并与胃复春片治疗48例对照观察，现报告如下。 　　1? 资料与方法 　　1.1? 诊断标准 　　CAG的纳入、排除、中医证候诊断及中医症状分级量化标准以及胃镜和病理标准均参照《中药新药临床研究指导原则(试行)》制定的标准［2］。 　　1.2? 一般资料? 　　全部112例均为本院中医科患者，门诊73例，住院39例，均经胃镜及病理检查确诊为CAG并伴有大肠不完全型IM和(或)ATP，中医辨证均属脾虚肝郁血瘀证。按照随机数字表法分为2组。治疗组64例，男39例，女25例；年龄26～65岁，平均(48.23±9.07)岁；病程1～26个月，平均(9.47±5.41)个月；CAG轻度17例，中度38例，重度9例；伴有大肠不完全型IM 47例，其中轻度15例，中度25例，重度7例；伴有ATP 29例，轻度8例，中度17例，重度4例。对照组48例，男31例，女17例；年龄28～62岁，平均(46.48±9.11)岁；病程1～20个月，平均(9.25±3.96)个月；CAG轻度13例，中度25例，重度10例；伴有大肠不完全型IM 35例，其中轻度11例，中度19例，重度5例；伴有ATP 16例，轻度4例，中度10例，重度2例。2组病例一般资料比较