哈尔滨医科大药学医学药理学课件-治疗充血性心衰药.pptVIP

治疗充血性心衰药Drugs used in heart failure Major effects of angiotensin II and the mechanism that mediate them * * Myocardial remodeling in Calcineurin transgenic hearts (Cell, Vol 93, 215-228,1998) Heart failure Reduced cardiac output Sympathetic nervous system activation Vasoconstriction Elevated cardiac filling pressure Sodium and water retention Angiotensin Ⅰ Renin Cardiac remodeling Aldosterone AngiotensinⅡ Pathophysiological mechanisms of heart failure and major sites of drug action digoxin β -blockers, digoxin Vasodilators ACE inhibitors Spironolactone Diuretics Angiotensin-R blockers Stru