10T淋巴细胞PPT.ppt

Selection of the T cell repertoire Precursors of T cell migrate from the bone marrow to thymus where only a small fraction mature and eventually leave as immunocompe- tent cell,as most die in the thymus. Upon entry into the thymus ,T cell initiate TCR rearrange- ment and this receptor is expressed on thymo -cytes that bear both CD4 and CD8 markers (double positive thymocytes) Positive and negative selection Once produced in the thymus, T cell undergo selection using their newly produced receptors. T cell with receptor which bind weakly t