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Generation of cytotoxic T lymphocytes Another consequence of the MHC antigen and T cell interaction is the induction of cytotoxic T?lymphocytes. When T?lymphocytes are cultured in the presence of allogeneic lymphocytes, in addition to undergoing mitosis (MLR), they also become cytotoxic to cells of the type that stimulated MLR (Figure 3). Thus, T?lymphocytes of x haplotype cultured over 5?7 days with B lymphocytes of y haplotype will undergo mitosis and the surviving T?lymphocytes become cytotoxic to cells of the y haplotype. The induction of mitosis in MLR requires disparity of only class?II antigens whereas the induction of cytotoxic T?lymphocytes (CTL) requires disparity of both class?I and class?II antigens. However, once cytotoxic cells have been induced, the effector cytotoxic cells recognize only class?I antigens to cause cytotoxicity. Generation of cytotoxic T lymphocytes Another consequence of the MHC antigen and T cell interaction is the induction of cytotoxic T?lymphocytes. When T?lymphocytes are cultured in the presence of allogeneic lymphocytes, in addition to undergoing mitosis (MLR), they also become cytotoxic to cells of the type that stimulated MLR (Figure 3). Thus, T?lymphocytes of x haplotype cultured over 5?7 days with B lymphocytes of y haplotype will undergo mitosis and the surviving T?lymphocytes become cytotoxic to cells of the y haplotype. The induction of mitosis in MLR requires disparity of only class?II antigens whereas the induction of cytotoxic T?lymphocytes (CTL) requires disparity of both class?I and class?II antigens. However, once cytotoxic cells have been induced, the effector cytotoxic cells recognize only class?I antigens to cause cytotoxicity. 1、急性GVHD 供受者HLA不相配或未对受者进行预防性处理时 移植后数天，最迟在术后2个月内即可发生 皮肤、肝脏、肠道等多个靶器官上皮细胞的坏死 皮肤瘙痒性斑丘疹、厌食、恶心、腹泻、血清胆红素增高等 由移植物中成熟T细胞介导，也可能与NK细胞有关 Acute graft-versus-host reaction with vivid palmar erythema? Early, chronic GVHD with widespread, almost confluent hyperpigmented lichenoid papules