宫颈癌终结版课件.pptVIP

宫颈癌Cervical cancer 湘雅医院妇产科　　 曹兰琴 副教授 一、Overview概述 Cervical cancer is the most common of the detected genital tract neoplasms, accounting for 50%-60% of the total. The disease is responsible for approximately 3% of cancer deaths. Recent years, the morbidity and mortality of cervical cancer has markly dropped. Patients of cervical cancer are more and more younger. 宫颈癌（cervical cancer） 二、Etiology 病因 HPV感染—宫颈癌 HPV的结构和分型 根据其致病性 高危型:HPV-16,18,33,45 低危型:HPV-6,11中危型 宫颈HPV感染 三、 Histology changes 组织发生和发展 The cervix surface is covered by two different kinds of cells. The out part is covered by squamous cells. The inner part is covered by column- shaped cells. The borderline zone of squamous cells and column-shaped cells is called squamocolumnar junction .The junction includes original and physiological junction.The area between original and physiological junction is called transformation zone. Cervical cancer occurs in this area. CIN (cervical intraepithelial neoplasia)宫颈上皮内瘤样病变 CIN: In the course of transformation zone formation,the squamous metaplasia is very active and stimulated by the external matters. Because of above two causes,squamous cells will change into dysplasia or cervical intra-epithelial neoplasia (shortned to CIN).CIN is graded into CINI,CINII,CINIII. There are mild, moderate and severe cervical cell changes. These conditions(CINⅠ，CINⅡ） are not cancer, but could later develop into cancer（CINⅢ） if left cancer untreat. 宫颈浸润癌的形成. Microinvasion cervical cancer: the cancer cells have just broken through the bottom layer of the skin of the cervix. At this stage, the cancer cells have not spread more than five millimeters into the tissues of cervix. Invasive cervical cancer : the cancer cells have spread from the surface skin of cervix into the deeper tissues of cervix. the cancer may also have spread to part of the vagina or to lymph nodes and other tissues surrounding the cervix with in pelvis or beyond pelvic area