帕金森病不同亚型患者的多巴胺转运体正电子发射断层显像研究_焦方阳.docVIP

————————————————————————————————————————————————————— 帕金森病不同亚型患者的多巴胺转运体正电子发射断层显像研究_焦方阳 262·· 论 著 帕金森病不同亚型患者的多巴胺转运体正电子发射断层显像研究 焦方阳1，武 猛2，王 坚3，司 展1，葛璟洁1，张慧玮1，蒋承峰1，管一晖1，左传涛1，吴 平1(1复旦大学附属华山医院PET中心 200235；2海军青岛江西路离职干部休养所卫生所 266071；3复旦大学附属华山医院神经内科 200040) 关键词　帕金森病；多巴胺转运体；亚型；正电子发射断层显像 摘要 目的 探讨帕金森病(PD)不同亚型患者多巴胺转运体(DAT)正电子发射断层显像(PET)的特点。方法　回顾性分析年龄、运动症状严重程度匹配的45例有明显震颤型(TDT组)和60例无明显震颤型(nTDT组)PD患者的临床和11C-CFT PET显像资料；另选择年龄匹配的健康对照者40名为对照组。对上述PD不同亚型患者的临床和影像学特征进行对比和相关性研究。结果　与对照组比较，TDT组和nTDT组在尾状核、前壳核和后壳核11C-CFT的摄取值均显著减低(Plt;0.001)。与nTDT组比较，TDT组患者的病程更长而进展更慢(Plt;0.05)，但两组在纹状体各部位11C-CFT的摄取值差异无显著性。前壳核和后壳核11C-CFT的摄取值与UPDRS Ⅲ运动评分、非震颤评分均呈显著负相关(P≤0.005)，而震颤评分仅在TDT组与后壳核11C-CFT的摄取值呈显著负相关(P=0.018)。结论　DAT PET显像有助于PD诊断和病情严重度评估，但不能用于PD不同临床亚型的鉴别。 Dopamine Transporter PET Imaging in Patients with Different Subtypes of Parkinson’s Disease　JIAO Fang-yang1,WU Meng2,WANG Jian3, SI Zhan1, GE Jing-jie1, ZHANG Hui-wei1, JIANG Cheng-feng1, GUAN Yi-hui1, ZUO Chuan-tao1, WU Ping1, 1PET Center, Huashan Hospital, Fudan University, Shanghai 200235; 2Health Care Center for PLA Navy Retired Cadres in Jiangxi Road, Qingdao 266071; 3Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China. KEY WORD Parkinson’s disease; dopamine transporter; subtype; positron emission tomographyABSTRACT Aim　The study investigated striatal dopamine transporter (DAT) binding characteristics in the patients with different subtypes of Parkinson’s disease (PD) by performing positron emission tomography (PET) imaging. Methods The clinical and 11C-CFT PET imaging data of age and motor severity-matched two groups of idiopathic PD patients were studied retrospectively: 45 with a tremor-dominant type (TDT) and 60 with a non-tremor-dominant type (nTDT). Clinical characteristics and 11C-CFT uptake were compared among groups and their correlations were evaluated. Results　11C-CFT uptake were [文章编号 ] 1008-0678(2015)03-0262-06 [中图分类号] R742.5 R817.4