Evaluation of Results of the Chagas Incidence 结果评价发病率.pptVIP

T. cruzi Incidence Study in Blood Donors and its Implications for One-time Testing of Blood Donors Robert Duncan, Ph.D. DETTD, CBER, FDA Blood Products Advisory Committee August 2, 2011 Background-1 Trypanosoma cruzi: causative agent of Chagas’ disease Small protozoan parasite Chronic, asymptomatic infection Difficult or impossible to treat, severe symptoms late in about 30% of cases Endemic to portions of Mexico, Central America, and S. America, 10 million people infected worldwide with 300,000 in the U.S. Transmission: feces of an infected triatomine insect, congenital, organ transplan