罗本燕-痴呆.PPT

* AD是慢性进行性的神经退行性病变，依患者疾病的严重程度，病程大致可分为三个阶段：轻度、中度、重度。在不同阶段，临床症状会逐渐加重。至终末期，患者丧失基本生活能力，终日卧床，大小便失禁。 Left) Structural healthy brain networks were obtained from diffusion MRI scans of 14 young healthy volunteers, followed by whole brain tractography. The nodes of this network correspond to cortical and subcortical gray matter regions obtained from a labeled T1-weighted brain atlas, and the edges of this network are proportional to the number and strength of the ?ber tracts that connect the nodes. Proposed network diffusion model and its eigenmodes are derived from this healthy network. The ?rst three eigenmodes, which we have hypothesized to be predictive of dementia atrophy patterns, are then tabulated and plotted. (Right) We then compare the predicted patterns with measured atrophy of dementia patients (AD, bvFTD, and age-matched normal subjects), obtained via a completely separate processing pipeline, available in the SPM Matlab toolbox. T1-weighted images of each subject were coregistered with the same atlas as in the left panel, and graymatter regions were parcellated using the prelabeled atlas information. Volume of each cortical and subcortical gray- matter region was measured. The atrophy of each region was obtained in terms of a t-statistic between the diseased and age-matched normal groups. Finally, the predicted and measured atrophy patterns were statistically compared using correlation analysis. * 这些标记物支持AD诊断，但鉴别AD与其他痴呆诊断时特异性低（39 – 90%），这可能与合并AD病理改变有关 目前尚缺乏统一的检测和样本处理方法 血管炎、感染或脱髓鞘疾病 * NMDA受体(N-methyl-D-aspartic acid receptor)即为N-甲基-D-天冬氨酸受体 * * * * β-secretase (also known as the β-site APP-cleaving enzyme;BACE1) initiates the amyloidogenic pathway because of aseptic meningoencephalitis in some patients, which was attributed to cytotoxic T cells and/or autoimmune reactions to AN-1972. CAD-106 is a vaccine that comprises the Aβ1–6 peptidewithout stimulating T cells and causing microhaemorrhages. Mitochondrial dysfunction occurs e