tissue disease结缔组织病课件.ppt

Connective tissue disease 國泰醫院皮膚科 Connective tissue diseases Lupus erythematosus Dermatomyositis/Polymyositis Scleroderma Others: Sj?grens syndrome Relapsing polychondritis Raynaud’s phenomenon ….. Lupus Erythematosus I. Cutaneous LE : A. Acute cutaneous LE (ACLE): 1. Localized ACLE (malar rash; butterfly rash) 2. Generalized ACLE B. Subacute cutaneous LE (SCLE): 1. Papulosquamous (psoriasiform) SCLE 2. Annular (polycyclic) SCLE C. Chronic cutaneous LE (CCLE): 1. Classic Discoid LE (DLE) a. localized DLE b. generalized DLE 2. Hypertrophic DLE 3. Lupus profundus/ Lupus panniculitis II. Systemic lupus erythematosus (SLE) American College of Rheumatology (ACR) Criteria for the Classification of SLEThis classification is based on 11 criteria: ＞＝4/11 diagnosis 1. Malar rash 2. Discoid rash 3. Photosensitivity 4. Oral ulcers, usually painless 5. Arthritis, nonerosive, involving two or more peripheral joints, with tenderness, swelling, or effusion 6. Serositis (pleurisy or pericarditis) 7. Renal disorder (persistent proteinuria exceeding 0.5 g/day or cellular casts) 8. Neurologic disorders (seizures or psychosis) 9. Hematologic disorders (hemolytic anemia; leukopenia of less than 4000/mm3; lymphopenia of less than 1500/mm3; or thrombocytopenia of less than 100,000/mm3) 10. Immunologic disorder (positive LE-cell preparation; anti-DNA in abnormal titer; antibody to Sm nuclear antigen; or false-positive serologic test for syphilis) 11. Antinuclear antibody (ANA) Systemic Lupus Erythematosus Cause: An autoimmune disorder involving multisystem inflammation and the generation of autoantibodies. The specific cause of SLE is unknown, immune system dysregulation leading to immune complex formation is postulated to induce tissue damage. Multiple influences, including genetic, racial, hormonal, and environmental factors, are associated with the development of SLE. Hormonal factors are suspe