医学毕业论文--小牛血去蛋白提取液对颅脑创伤患者SB蛋白演变和病情的影响.doc

小牛血去蛋白提取液对颅脑创伤患者S100B蛋白演变和病情的影响 【摘要】 目的：观察颅脑创伤后血清S100B蛋白水平的变化，探讨小牛血去蛋白提取液对颅脑创伤的治疗作用和对S100B蛋白的影响。方法：急性颅脑损伤患者68例随机分成常规组和实验组，另选30例健康人员作为对照组。在常规治疗基础上实验组采用小牛血去蛋白提取液治疗1周，常规组不予小牛血去蛋白提取液治疗，检测并比较伤后3、8、24、72 h和1周血清S100B蛋白水平，并观察治疗1周后两组的病死率。结果：伤后3、6、24h常规组和实验组S100B蛋白水平均明显高于对照组，差异有统计学意义(P均lt;0.05)，伤后24 h常规组S100B蛋白水平明显高于实验组(Plt;0.05)。治疗1周后实验组颅内压明显低于常规组(Plt;0.05)，GCS评分明显高于常规组(Plt;0.05)，病死率(2.94%)明显低于实验组(22.22%)(Plt;0.05)。结论：颅脑创伤后血清 S100B蛋白可以作为反映小牛血去蛋白提取液对脑损伤治疗程度的标志物，小牛血去蛋白提取液对损伤的脑组织有治疗作用。 【关键词】 小牛血去蛋白提取液;S100B蛋白;颅脑创伤 　[ABSTRACT] Objective: To investigate the changes of serum S100B in patient with craniocerebral trauma, and the therapeutic effects of free protein serum of cow injection (FPSCJ) on craniocerebral trauma and the influences of FPSCJ on serum S100B. Methods： 68 patients with acute craniocerebral trauma were divided randomly into experimental group (EG) and conventional group (CG), other 30 healthy persons were selected as control. In additional to routine therapy, experimental group was introduced FPSCJ for one week, routine therapy were operated in control group. Serum levels of S100B were detected at 3, 6, 24, 72hs and one week after trauma, and then the results were compared. The mortality in two groups was evaluated after one week treatment. Results： The S100B levels were significantly higher in both conventional and experimental groups (both Plt;0.05)than that in control at 3, 6, 24hs after trauma, it was higher in CG than that in EG(Plt;0.05) at 24hs after trauma. After one week treatment, intracranial pressure was much lower in EG than that in CG(Plt;0.05), GCS score was higher in EG(Plt;0.05), and the mortality in EG was lower than in CG(2.94%/22.22%)(Plt;0.05). Conclusion： Serum S100B can be a prognostic marker for patients treated with FPSCJ, and FPSCJ has therapeutic effects on craniocerebral trauma. 　　[KEY WORDS] Free protein serum of cow injection; S100B; Craniocerebral trauma 　　小牛血去蛋白提取物含有小分子多肽、氨基酸、低聚糖等多种生物活性物质，可增强组织细胞对氧及葡萄糖的摄取及利用，促进线粒体的氧化磷酸化过程，改善细胞能量代谢，