兰索拉唑对经皮内镜下胃造瘘术并发症防治临床研究.docVIP

兰索拉唑对经皮内镜下胃造瘘术并发症防治临床研究 　　[摘要] 目的 探讨兰索拉唑对经皮内镜下胃造瘘术（PEG）并发症的防治作用。 方法 选择我院收治的鼻咽癌患者90例，分为对照组、1周治疗组和2周治疗组，每组30例，对照组行PEG肠内营养，1周治疗组和2周治疗组行PEG肠内营养后分别予兰索拉唑治疗1周和2周，分析4周后三组患者的营养指标和并发症的发生情况。 结果 术后三组患者营养指标较术前明显改善（P0.05）。结论PEG能改善患者的营养情况，术后使用兰索拉唑1周，能降低并发症的发生。 　　[关键词] 经皮内镜下胃造瘘术；兰索拉唑；并发症 　　[中图分类号] R730.5 [文献标识码] B [文章编号] 1673-9701（2014）02-0051-03 　　Clinical study on lansoprazole for percutaneous endoscopic gastrostomy complications prevention and treatment. 　　GUO Hongxing1 GAO Ke1 CHEN Xi2 DENG Qingwen1 TANG Ronghui1 DENG Ruihua1 　　1.Department of Gastroenterology， the Fifth Affiliated Hospital of Southern Medical University， Guangzhou 510900， China； 2.Department of Otolaryngology， the First Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510900， China 　　[Abstract] Objective To investigate the role of lansoprazole for percutaneous endoscopic gastrostomy（PEG） complications prevention and treatment. Methods Researched ninety patients with nasopharyngeal carcinoma in our hospital. The patients were divided into control group， one week treatment group and two weeks treatment group， with each group thirty cases. The control group received PEG enteral nutrition， one week treatment group and two weeks treatment group were respectively given lansoprazole treatment one week and two weeks after received PEG enteral nutrition. The three groups patients of nutritional indicators and the incidence of complications were analysed after four weeks. Results The three groups patients after surgery compared with preoperative nutritional parameters improved significantly （P0.05）. Conclusion PEG can improve the patients nutritional status； postoperative use of lansoprazole one week， can reduce the incidence of complications. 　　[Key words] Percutaneous endoscopic gastrostomy； Lansoprazole； Complications 　　1980年经皮内镜下胃造瘘术被介绍应用于临床[1]，30多年来PEG临床应用的范围不断扩展，越来越受到重视，该项技术已在欧美、日本等国家替代外科胃造瘘，目前PEG已经成为需要长期肠内营养支持患者的首选方法，但其并发症如吸入性肺炎、反流性食管炎、上消化道出血、消化性溃疡等的发生率却不容忽视。然而，目前国内尚无有效防治该并发症发生的临床研究，本研究探讨兰索拉唑防治P