孕妇生殖道感染对胎膜早破早产和分娩方式及IL—12和IL—18影响.docVIP

孕妇生殖道感染对胎膜早破早产和分娩方式及IL—12和IL—18影响 　　[摘要] 目的 探讨孕妇生殖道感染对胎膜早破早产、分娩方式和IL-12、IL-18的影响，以期为临床工作提供帮助。方法 收集我院有生殖道感染的孕妇89例作为观察组，收集无生殖道感染的孕妇89例作为对照组，分析两组相关指标的差别。 结果 观察组与对照组在母体病率、胎盘病理阳性率、新生儿并发症发生率、先兆流产、早产、胎膜早破及剖宫产发生率的差别均有统计学意义，观察组阴道分泌物中白细胞介素-12（IL-12）和白细胞介素-18（IL-18）的表达明显高于对照组。结论 孕妇生殖道感染可以增加不良妊娠结局的发生率，且阴道分泌物中IL-12和IL-18的表达升高，临床应对妊娠妇女进行常规生殖道感染方面的检测，以早期发现，早期治疗。 　　[关键词] 孕妇生殖道感染；妊娠结局；白细胞介素-12；白细胞介素-18 　　[中图分类号] R714.4 [文献标识码] B [文章编号] 1673-9701（2014）02-0135-03 　　The influence on PPROM， mode on delivery， expressions of IL-12 and IL-18 in pregnant women with reproductive tract infection 　　XU Fengqiu1 DU Xiaodong1 CHEN Jianmei2 　　1.Department of Gynaecology and Obstetrics， Maternal and Child Health Hospital of Lishui City in Zhejiang Province， Lishui 323000， China； 2.Department of Gynaecology and Obstetrics， Lishui Peoples Hospital in Zhejiang Province， Lishui 323000， China 　　[Abstract] Objective To study the influence on PPROM， mode on delivery， expressions of IL-12 and IL-18 in pregnant women with reproductive tract infection， for providing support to clinical treatment. Methods A total of 89 pregnant women with reproductive tract infection were collected as the observation group， 89 normal pregnant women were collected as the control group. The related index were analyzed in the two groups. Results There were obviously significantly different on maternal disease rate， placental pathological positive rate， neonatal complication rate， threatened abortion， premature delivery， premature rupture of membranes and cesarean section rate in the two groups. The expressions of IL-12 and IL-18 of vaginal secretion were higher in the observation group than in the control group. Conclusion The genital tract infection can increase the incidence rate of adverse pregnancy outcome， increase the expressions of IL-12 and IL-18 of vaginal secretion. The reproductive tract infection should be prevented early in clinical work. 　　[Key words] Genital tract infection； Pregnancy outcome； IL-12； IL-1