高同型半胱氨酸血症与糖耐量及2型糖尿病的关系-第三军医大学学报.DOC

2型糖尿病患者血清同型半胱氨酸水平变化及其影响因素 易吉秀1 ，瞿华2 ，胡振平2 ，王行2 ，邓华聪2﹡（1. 黔江中心医院；2. 重庆医科大学附属第一医院内分泌科400016 ） *通讯作者：邓华聪，Email: deng_huacong@ 【摘 要】目的：探讨2型糖尿病患者血清同型半胱氨酸（Homocysteine，Hcy）水平变化及其影响因素。方法：41例新诊断的2型糖尿病患者(DM组)，30例正常对照组(NGT组)，行口服葡萄糖耐量试验(OGTT);应用化学发光法检测血清同型半胱氨酸水平；稳态模型计算HOMA-IR。探讨2型糖尿病时同型半胱氨酸水平变化与血糖、血脂、胰岛素及HOMA-IR的关系。结果：(1)DM组Hcy显著高于NGT(P0.05).(2)同型半胱氨酸与、BMI、腰围、DBP、FPG、2HPG、TC、TG、LDL-c、HOMA—IR呈显著正相关，与FIN呈显著负相关性，有统计学差异；。(3)多元逐步回归分析显示，HOMA—IR、BMI、舒张压、FPG与血清Hcy水平显著相关。结论：1、2DM患者血清Hcy水平明显高于NGT人群，存在高同型半胱氨酸血症；2、HOMA—IR、BMI、DBP、FPG是Hcy水平变化的重要影响因素，Hcy与胰岛素抵抗发生密切相关。 关键词：同型半胱氨酸；葡萄糖耐量； 2型糖尿病；胰岛素抵抗 THE INVESTIGATION ON THE CHANGE OF SERUM HOMOCYSTEINE AND IT’S INFLUENCING FACTORS IN TYPE 2 DIABETES MELLITUS YI Ji-xiu1,QU Hua2,Hu Zhen-ping2,Wang Hang2,Deng Hua-cong2* (1. 2.Department of Endocrinology ,The First Affiliated Hospital, Chongqing Medical University,chongqing 400016,china) [Abstract] 华聪响的检测系tolerances th the HOMA-Iobjective To investigate the change of serum homocysteine and the relationship between hyper homocysteine and glucolipid metabolism. insulin resistance in type 2 diabetes. Methods 41 patients with newly diagnosed type 2 diabetes mellitus (DM group), 30 subjects of normal glucose tolerance (NGT group) were conducted by oral glucose tolerance test (OGTT). Serum homocysteine was detected by chemiluminescence method，homeostasis model assessment for insulin resistance (HOMA-IR) was calculated to explore the relationship between homocysteine and blood glucose, lipid, insulin, HOMA-IR. Results (1)The Hcy in DM group was significantly higher than those in NGT group (P0.05). (2) Hcy was positively correlated to BMI，waistline，DBP，FPG, LDL-C, HOMA-IR, and negatively correlated to FINS. (3)Multiple regression stepwise analysis showed that HOMA-IR、BMI、DBP、FPG were important factors affecting hyperhomocysteine. .Conclusion There is hyperhomocysteinem