喜炎平联合康复新液治疗手足口病临床观察.docVIP

喜炎平联合康复新液治疗手足口病临床观察 nt group 140 cases and control group 134 cases. Two groups were to be antipyretic treatment, combined with bacterial infection to antibiotic treatment, the treatment group were treated with intravenous injection, with Kangfuxin liquid oral and topical,the control group was given Virazole injection intravenous drip, with lidocaine, montmorillonite suspension with oral, compared with two groups of clinical symptom improvement and effect. Results The treatment group total efficiency is higher than that of the control group,the treatment group cavity ulcer healing time, rash subsided, the feed improvement to the normal time, defervesce time than in the control group was significantly shorter(P0.05). Conclusion Xiyanping combined with Kangfuxin liquid in treatment of hand foot and mouth disease common type, patient compliance is good, the side effect is small, safe and effective. 　　【Key words】 Hand foot mouth disease；Treatment；Xiyanping；Kangfuxin liquid 　　 手足口病是由肠道病毒(以柯萨奇A组16型(CoxA16)、肠道病毒71型(EV71)多见)引起的急性传染病，主要症状表现为手、足、口腔等部位的斑丘疹、疱疹。少数病例可出现脑膜炎、脑炎、脑脊髓炎、肺水肿、循环障碍等，多由EV71感染引起，致死原因主要为脑干脑炎及神经源性肺水肿［1］。目前小儿手足口病尚无特效西药治疗,以中西医结合治疗的疗效最好,多采用对症治疗,临床症状缓解慢,多数患儿因口腔溃疡疼痛拒食,严重影响患儿生活质量。我科采用喜炎平注射液静脉滴注联合康复新液口服及外用治疗普通型手足口病取得了满意的疗效,现报告如下。 　　1 资料与方法 　　1.1 一般资料 2009年3至2011年6月本院儿科确诊手足口病患儿274例。将全部病例随机分为两组:治疗组140例,对照组134例。治疗组中男72例,女68例,年龄8个月至10岁，平均年龄(2.9±1.1)岁，发热79例(53.4%)，皮疹140例(100%)，口腔溃疡92例(65.7%)；对照组中男68例,女66例,平均年龄(3.0±1.2)岁，发热,74例(55.2%)，皮疹134例(100%)，口腔溃疡89例(66.4%)。两组患儿性别、年龄、症状(发热)、体征(皮疹)差异无统计学意义(P0.05),具有可比性。 　　1.2 诊断标准 根据卫生部制定的“手足口病诊疗指南(2008年版)手足口病普通型诊断标准［1］。临床诊断病例:在流行季节发病,常见于学龄前儿童,婴幼儿多见。发热伴手、足、口、臀部皮疹,部分病例可无发热。排除标准：考虑诊断为手足口病重型及危重型病例。出现神经系统受累、心肺等系统并发症。 　　1.3 治疗方法 治疗组给予喜炎平注射液5~10 mg/kg，加入5％或10％葡萄糖注射液稀释后静脉滴注，1次/d，连用3～7ｄ,同时口服康复新液(四川好医生攀西药业有限责任公司生产),≤1岁2 ml/次,1岁3 ml/次,1次/d,并用浸透药液的棉签涂抹口腔及皮肤皮疹,4次/d；对照组给予利巴韦林注射液10~15 mg/(kg?d),静脉滴注，1次/d, 连用5～7 d，加用利多卡因与蒙脱石散混合液涂抹口腔患处,4次/d。 两组均给予相同的对症支持治疗,体温38.5℃者予以口服退热剂,合并细菌感染给予抗生素治疗，完全不能进食者给予氨基酸等支持。 　　1.4 观察指标 每日记录口腔溃疡愈合、皮疹消退、进食恢复及体温恢复情况。