内皮功能和心血管危险因素薛增明课件.ppt

* Superoxide measured 3 hours after morning dose of ISMN (200 mg/kg/day) (Huge dose; nitrate tolerance) * * * * * * * * * * * * * * * * * * * * Had positive SPECT scan. * * * * * * Why did some trials show vitamins to be detrimental? * * Why did some trials show vitamins to be detrimental? * * * * It is important to know that the significance of NO release from the endothelium is much less likely its dilator effects as it is the antiatherosclerotic effects of NO. Interestingly EETs share many of the same properties of NO in this respect. So one might argue that EET/EDHF is a better antiather