纳洛酮与醒脑静联合抢救COPD并Ⅱ型呼吸衰竭临床观察.docVIP

纳洛酮与醒脑静联合抢救COPD并Ⅱ型呼吸衰竭临床观察 　　[摘要] 目的 探讨纳洛酮与醒脑静联合抢救慢性阻塞性肺部疾病（COPD）并Ⅱ型呼吸衰竭的临床效果。 方法 将256例COPD并Ⅱ型呼吸衰竭患者随机分为治疗组与对照组。治疗组128例采用纳洛酮联合醒脑静治疗，对照组128例用常规方法治疗。 结果 治疗组总有效率（98.44%），对照组总有效率为95.31%，两组比较差异无统计学意义；而治疗组显效率为88.28%，明显高于对照组52.34%，差异有统计学意义；血气分析：两组比较差异无统计学意义；动脉血气分析指标：动脉血氧分压（PaO2）明显高于对照组（P 0.05），差异无统计学意义。 结论 纳洛酮与醒脑静联合治疗性阻塞性肺气肿并Ⅱ型呼吸衰竭临床疗效确切。 　　[关键词] 纳洛酮；醒脑静；Ⅱ型呼吸衰竭 　　[中图分类号] R563.8 [文献标识码] B [文章编号] 1673-9701（2013）07-0130-03 　　Clinical observation of the naloxone-Xingnaojing joint rescue COPD and typeⅡrespiratory failure 　　ZHU Minghui1 HU Guangfen1 LI Jinglin2 　　1.The Emergency Department of the First Peoples Hospital of Guangzhou Hedong Branch， Guangzhou 510180， China；2.The Emergency Department， the First Peoples Hospital of Guangzhou， Guangzhou 510180， China 　　[Abstract] Objective To investigate the effectiveness of naloxone with Xingnaojing joint rescue chronic obstructive pulmonary disease （COPD） and type Ⅱ respiratory failure clinical observation. Methods A total of 256 patients with COPD and type Ⅱ respiratory failure were randomly divided into two groups： the treatment group and the control group. 128 cases in the treatment group， be treated by naloxone with Xingnaojing of treatment， 128 cases in control group be treated by traditional methods. Results The overall effective rate for treatment group was 98.44%， and the overall effective rate of the control group is 95.31%. There were not significant differences on overall effectiveness between the two groups. While the dominant effective rate for treatment group is 88.28%， that of the control group was 52.34%， the dominant effectiveness for treatment group was significantly higher than the control groups. Blood gas analysis indicated the treatment group and the control group showed no significant differences. The arterial blood gas analysis indicated the arterial partial pressure of oxygen （PaO2） was significantly higher than that in the control groups （P 0.05） and there is not significant differences on PaCO2.