胃肠结外淋巴瘤课件.pptVIP

肠病型小肠T细胞淋巴瘤(EATL) 通常有谷蛋白敏感性肠病既往史 腹腔疾病患者: Relative risk of EATL x 50-100 临床表现: 多发空肠溃疡 Extension: GI tract : estomac, colon Extra-intestinal : blood, skin, lung EATL EATL 粘膜内T淋巴细胞增殖 Phenotype T CD3+CD4- CD8-/+ TCR- CD103+ Phenotype T cytotoxic TIA1+ granzyme B+ Granzyme B CD103 组织学表现 治疗 不含谷蛋白膳食 No good chemotherapy OS poor 1 year = 35% 5 years = 20% EATL 结论 结外淋巴瘤具有独特的临床病理特征 胃肠道淋巴瘤最常见 多数与慢性抗原刺激相关 治疗应采取个体化 * * 20 * * * MZL and particularly MALT lymphoma is believed to be an antigen-dependent disease. Persistent antigenic challenge causes a chronic inflammatory reaction wich can in some pe