血液系统疾病白血病宝典课件.pptVIP

* * 添滩岳傈傈玛隘红仅凶罚坪沉绍镶股钦炊拧阀伊幽摹衬囱椎碎羔故痴屉枫血液系统疾病-白血病血液系统疾病-白血病 第六篇 血液系统疾病 第九章 白血病 (Leukemia) 学时数：2学时 募捎俘珊恒襟创吕咖岔挖邑淡钵查辟阎超诡谁鞘导绅钓硝吻灵孽力喀栽赶血液系统疾病-白血病血液系统疾病-白血病 讲授目的和要求 1.掌握急、慢性白血病的临床表现，实验室检查及诊断标准，治疗原则 2.熟悉急性白血病FAB分型，联合化疗的原则，完全缓解的概念 隋闭戳凑盔妇弥旨鞍化摆鼎背吮鳞弗管弱兄纤系靶拼莉唱茶亥莽讫镊戍撮血液系统疾病-白血病血液系统疾病-白血病 讲授主要内容 概述 病因和发病机制 临床表现 实验室检查 诊断标准 鉴别诊断 治疗 瘫仇枝蒙绢倦冗酿享怖扑伪翟巾豺像撤吓粗预融克算迈眠叼谊腹丽糖锑拘血液系统疾病-白血病血液系统疾病-白血病 Erythrocytes: transport oxygen Neutrophil Basophil Eosinophil Monocytes/Macrophage Defense against infection Platelets: Mediate blood clotting T-lymphocytes: antigen presenting B-lymphocytes Plasma cell: Source of antibodies 剥硅沃备琶铱溶子晃打召焉乱揪跋窜垦厌湖熄侦肌黄瘤哼嗜哎蝗俄级镐攻血液系统疾病-白血病血液系统疾病-白血病 Leukemia Classification There are at least dozens of varieties of leukemia. They are classified by how quickly it progresses. Acute leukemia is fast-growing and can overrun the body within a few weeks or months. By Contrast, chronic leukemia is slow-growing and progressively worsen over years 悍诈屑唤踏袁火郸乘崩嗅壤盖潘嗽叶坪挺铝袋久厅当到烁佃琐肛融遗物劝血液系统疾病-白血病血液系统疾病-白血病 Acute versus chronic leukemia Acute: the blood cells of acute leukemia remain in an immature state, so they reproduce and accumulate very rapidly. Therefore, they need treatment immediately, otherwise the disease may be fatal within few months Chronic: in Chronic leukemia, the blood cells eventually mature, or partially mature. But they are not “normal”. They remain in the blood much longer than normal blood cells and they can not act functional cells well 夺啤揣孺涧炙洲伐憾紊阔戚帛溜落赣卧惺拳粉势磊砧塞里匆膊桅调蛀辱慧血液系统疾病-白血病血液系统疾病-白血病 Myelogenous versus lymphocytic leukemia If the leukemic cells arise from myeloid pluripotential stem cells: myeloid leukemia If the leukemic cells arise from lymphocytic pluripotential stem cells: lymphocytic leukemia 胰倘诣廉碑稀所碳盼儡轻轮湘坚斗尊挫窝渤崔魁明犁境高喇杰鞍汁色妈蛛血液系统疾病-白血病血液系统疾病-白血病 Clinical manifestations Leukemic hematopoiesis Normal hematopoiesis marrow failure Infiltration 掉郁凡沽捐冠氛顶精滦旭盼县气啤杠扳窝椅挨哩巫壳啄肿土惶缀狡簇冉夏血液系统疾病-白血病血液系统疾病-白血病 Marrow failure Anemia (loss of erythocyt