抗阿米巴病和抗滴虫病药和抗肠蠕虫药课件.pptVIP

 Anti-amebiasis and anti-trichomoniasis drugs (抗阿米巴病和抗滴虫病药)  Anthelmintic drugs (抗肠蠕虫药)? A. Anti-amebiasis and anti-trichomoniasis drugs (抗阿米巴病和抗滴虫病药) Life cycle of amebic parasite Classification of amebiasis: Luminal amebiasis(肠内阿米巴): Amebic dysentery(阿米巴痢疾), Asyptomatic carrier(无症状带虫者) Systemic amebiasis(肠外阿米巴) Amebic hepatitis(阿米巴肝炎), hepatic abscess(阿米巴肝脓肿) 　 Mixed amebiasis. The drugs used in amebiasis: Metronidazole(甲硝唑), Tinidazole(替硝唑); Emetine(依米丁), Dehydroemetine; Halogenate quinolines(卤化喹啉类): Chiniofon(喹碘仿), Clioquinol(氯碘羟喹), Diiodohydroxyquinoline(双碘喹啉); Diloxannide(二氯尼特); Paromomycin(巴龙霉素); Chlorpromaquin(氯喹), etc. Metronidazole(甲硝唑, 灭滴灵) (1)Pharmacological effects clinical uses: ①Anti-amebiasis effects: It has potent amebicidal activity to large trophozoite(大滋养体) grown, but no affect to small trophozoite(小滋养体). Effective to acute amebic dysentery and all systemic amebiasis, but ineffec-tive to asyptomatic passers. Therefore, it need be used comban-tion of purely intestinal amebicides, such as diloxanide to radically treatment. ②Anti-trichomoniasis effects: Metronidazole can kill Trichomonas vaginalis(阴道毛滴虫) directly. After oral administration, it is absorbed fast, distribute to the whole body, and secreted into vaginal secretion(in female), sperm(in male) and urine. Therefore, it is effective toTrichomonas infection of male and female. Its curative rate(治愈率) reach 90%. ③Anti-anaerobic bacteria infection: The sensitive anaerobic bacteria to metronidazole including: ▲All anaerobic cocci(所有的厌氧球菌); ▲G- anaerobic bacillus(G-厌氧杆菌) and G+ spore anaerobic bacillus(G+芽孢厌氧杆菌); Therefore, this drug is used to treat: 1)vary anaerobic bacteria infection of pelvic cavity and abnormal cavity; 2)peridentitis(牙周炎); 3)infection of helicobacter pylori (HP) also, HP is the main cause of gastric and duodenal ulcer. ④Anti-giardiasis: