Anti-oxidant status in patients with Rheumatoid Arthritis ：抗氧化状态的患者与类风湿性关节炎.pptVIP

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2018-06-23 发布于浙江
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Anti-oxidant status in patients with Rheumatoid Arthritis ：抗氧化状态的患者与类风湿性关节炎.ppt

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Anti-oxidant status in patients with Rheumatoid Arthritis ：抗氧化状态的患者与类风湿性关节炎

Anti-oxidant status in patients with Rheumatoid Arthritis after Spa Therapy Dr. Mine Karagülle Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. Reactive oxygen species (ROS) produced in the course of cellular oxidative phosphorylation, and by activated phagocytic cells during oxidative bursts, exceed the physiological buffering capacity and result in oxidative stress. The excessive production of ROS can damage protein, lipids, nucleic acids, and matrix components. They also serve as important intracellular signaling molecules that amplify the synovial inflammatory–proliferative response. Plasma lipid peroxidation and antioxidant levels in patientswith rheumatoid arthritisA.Kamanl?, M.Nazro?lu, N. Aydilek, C.HacevliyagilCell Biochem Funct 2004; 22: 53–57. increased lipid peroxidation and decreased enzymic and non-enzymic antioxidants in RA oxidant stress plays a very important role in the pathogenesis of RA. Antioxidant status lipid peroxidation in patients withrheumatoid arthritisF. Karata?, I. ?zate?, H. Canatan, I. Halifeo?lu, M. Karatepe, R. ?olakIndian J Med Res 118, October 2003, pp 178-181 There was an increased oxidative stress and a low antioxidant status in patients with RA. These changes are probably due to efforts for reducing lipid peroxidation and hence to lower tissue damage. This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels were measured to establish plasma oxidant/antioxidant status in the patient and control groups. These results could be seen as an indication of reduced antioxidant capacity and oxidant stress in RA patients suggest that the antioxidant system is impaired and peroxidation reactions are accelerated in patients wit