Alcohol and Dementia - Alz：酒精和痴呆-公司.pptVIP

* ASSOCIATION BETWEEN ALCOHOL CONSUMPTION AND COGNITIVE IMPAIRMENT IN CHINESE OLDER ADULTS(Chu LW, Chan KKK, Chiu KC) Prof. Leung-Wing ChuMD, FRCP (Edin. Glas.), FHKCP, FHKAM (Medicine) Honorary Clinical Professor, Department of Medicine,, LKS Faculty of Medicine, The University of Hong Kong Chief, Division of Geriatrics, Queen Mary Hospital OC051 March 28, 2011 * Conflict of Interest All authors Chu LW, Chan KKK, Chiu KC Has no real or apparent conflicts of interest to report OC051 * Introduction Alcohol consumption - diverse effects on heart brain health Coronary heart diseases, Moderate consumption ? beneficial effects in heart diseases; possibly too for vascular dementia Brain’s cognitive functioning: Previous studies light to moderate alcohol consumption (up to 3 glasses of wine daily) ? lower risks of cognitive impairment (CI) dementia vs. non-drinker (Ruitenberg et al, 2002, Rotterdam study several other Western studies) ? 38% reduced risk of CI in a systematic review (Peters et al, 2008) MCI (mild cognitive impairment): Light alcohol consumption of up to one drink/day ? decrease progression from MCI to dementia (Solfrizzi, 2007) * Introduction Very limited data reported fron Chinese populations Only 2 studies from mid-China provinces But with different findings Alcohol ?increased the risk of dementia in a dose-related manner (Zhou et al, 2003) Light-moderate alcohol intake ? 50% reduction in dementia (both VaD AD) (Deng et al, 2006) No Chinese study from Southern part of China * Objective of the study To investigate the association between alcohol consumption and the risk of cognitive impairment in Southern Chinese older adults in Hong Kong. * Methods Design: A a cross-sectional study Setting: Geriatric Clinics of Queen Mary Hospital and Grantham Hospital, The University of Hong Kong, Hong Kong SAR ( a southern city in China). Subjects’ inclusion criteria:- Chinese ethnicity, aged 65 years old or over, and written informed consent Exc