Pandemic Influenza Antiviral Strategies and Priority Groups流感大流行的抗病毒策略和优先级组.pptVIP

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Pandemic Influenza Antiviral Strategies and Priority Groups流感大流行的抗病毒策略和优先级组.ppt

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Pandemic Influenza Antiviral Strategies and Priority Groups流感大流行的抗病毒策略和优先级组

Pandemic Influenza Antiviral Strategies and Priority Groups Andrew T. Pavia M.D. University of Utah Outline Process Principles, Key Data, Assumptions Working Group Recommendations Optimal size and minimal size Drugs of choice Priority Groups and Strategies for Limited Supply International containment Critical research issues Working Group Process Meeting April 19-20, 2005 Construction of “Straw Man” proposal Conference Call with Wisconsin DOH Conference Call May 24, 2005 Joint meeting in Atlanta June 15-16, 2005 Coordination with Vaccine working sub-group Presentations – June 15, 16 Meeting Goals Estimates of pandemic influenza impact Impact of annual and pandemic flu in different age and risk groups Impact of pandemic influenza on the healthcare system and options for prioritizing among healthcare workers Definition of critical infrastructure and possible prioritization of infrastructure support groups Presentations – June 15, 16 Meeting Ethical considerations Impacts of oseltamivir in a mouse model of H5N1 infection Mathematical modeling of strategies to contain an influenza outbreak and prevent pandemic spread CDC antiviral planning activities Implementation of an antiviral response at the State level. Principles of Antiviral Drug Use - 1 Primary goal of response is to decrease pandemic health impacts (social secondary; economic tertiary) Given the uncertainties about antiviral drug use and supply, strategies must be flexible, and must be re-addressed as a pandemic unfolds National guidelines provide guidance and achieve consistency. However, State and local health departments should have flexibility to meet local needs Principles of Antiviral Drug Use - 2 Delivery of antiviral drugs should be equitable within target populations and not constrained by ability to pay Antiviral drug use strategies must be Feasible to implement Acceptable to the public Transparent Key Data Treatment with a NA inhibitor within 48 hours decreases lower respiratory complicati