益生菌转化医学的研究及趋势.pptVIP

Comprehensive probiotics solution 感谢您的关注！ Researches on Probiotics Translational Medicine and the Trends 益生菌转化医学的研究及趋势 * Binhai Shi Ph.D 2014.10.31 * What is Probiotics? 1. Live microorganisms which when administered in adequate amounts confer a health benefit on the host. (FAO/ WHO, 2001) Yogurts, Beverages, Solid drinks. General Food Gut flora, Immunity. (52 products) Health Food GI diseases (22 products) Medicine Probiotic Products * Researches 2. Dr. Mechnikov (?Nobel?Laureate of 1908) Mechnikov theorized that the Bulgarians lived so long because they consumed so much yogurt. In 1905 “The Prolongation of Life” was published, developping a theory that?aging?is caused by toxic bacteria in the gut and that?friendly bacteria (Probiotics)?could prolong. Origin of Probiotics * Ref: Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria, (2001) Disorders of GI tract Diarrhoea、AAD H. pylori infection Inflammatory diseases and BS Cancer Constipation Mucosal immunity Allergy Cardiovascular disease Urogenital tract disorders Bacterial vaginosis Urinary tract infections Dibetes Hyperlipidemia Obesity Liver health Gut-Brain Axis Recent Studies Health Benefits Clinical Researches Primary endpoints Number of reports (%) Intestinal healing 88 (37%) Immune-modulation 53 (22%) Infection prevention 49 (21%) Others 46 (19%) The annual number of probiotics clinical studies published (Ref: Chonan et al, Milk Science 2011) Gut microbiota Cognition Metabolism Immunity 1990 2000 2010 2020 2030 * Researches on Metabolism Nature, 457:480-484, 2009 A metagenome-wide association study of gut microbiota in type 2 diabetes Nature, 490: 55-60, 2012 An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice The ISME Journal,?7:880–884, 2013? * Trends 3. * Product Trends High potency