锥虫（Trypanosoma）表面抗原转换机制课件_1.ppt

锥虫(Trypanosoma)表面抗原转换机制 ;一、锥虫抗原变异现象;二、锥虫表面变异抗原（VSG）的组成;三、锥虫VSG表达的遗传基础;;四、锥虫表面抗原（VSG）转换机制;;; 五、锥虫VSG变异规律;六、锥虫VSG基因变异与宿主的关系; 七、结语;谢 谢!;Fig1. Minichromosomes (red) and large chromosomes (yellow) exhibit different positional dynamics during mitosis. DNA(blue) ;Fig2：Schematic representation of a trypanosomal variant surface glycoprotein(VSG) gene expression site.Modelled after Revelard et al.and Lips et al.The flag indicates the promoter ,the number in the box indicate the expression site-associated genes (ESAGs), V indicates the VSG gene,and End indicates the chromosome terminus.The enlargements show feature of ESAG6 and ESAG7,which encode subunits of the Tf-R.;Fig2：Schematic representation of a trypanosomal variant surface glycoprotein(VSG) gene expression site.Modelled after Revelard et al.and Lips et al.The flag indicates the promoter ,the number in the box indicate the expression site-associated genes (ESAGs), V indicates the VSG gene,and End indicates the chromosome terminus.The enlargements show feature of ESAG6 and ESAG7,which encode subunits of the Tf-R.;Fig2：Schematic representation of a trypanosomal variant surface glycoprotein(VSG) gene expression site.Modelled after Revelard et al.and Lips et al.The flag indicates the promoter ,the number in the box indicate the expression site-associated genes (ESAGs), V indicates the VSG gene,and End indicates the chromosome terminus.The enlargements show feature of ESAG6 and ESAG7,which encode subunits of the Tf-R.;)ZfU9sATl4qS83OsC-nOmEprm+pW*Q!vpqownk1lIdzd9!9sLi)VUBuj5-Pj(v7-Y!2Lt55PyBkNHV8id)L7*rwihZQp4(8%3GQqubnqh84EASv4-sP$Y$GORePCrAWvHBGCOWPiz4J1fvzx#i8+q)O(x$vw60kk#Qd8FJLHgTPMW(j9mcWNtoLWtXQ!OOAdV0wjfH9k)EuSs6qsUJu-YVhUKU4#c%2PsQxi*2K5kPplLVbeR$NdM9*Zr1jW6446BJdg4zvegiww6z$DG2olOw4#-0C9YydzjL0GW!stkC1nwrhNdwtCA)88P!y)MyYNrjrFP15Nd2oNg#ExUGAwO2sl(uIOx*uYmj)9mG*l4$VmH5Nste7aYC8Eb5pU3IOo1b)L1(F%M7)SvNsnTrBWPP6#ThgvaVN7MJl3#S!*gmrWfXEEuIQ65hjYmWqV4g6kH9Q(77vrvshbq%B3XSDpbPeSmPiQPu2+eAb$s%LNyXqBQlhM1Itm2Bpvdi(mS