Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 海基会抑制成纤维细胞生长因子通过抑制FGFR1信号.pptVIP

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2018-06-24 发布于四川
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Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 海基会抑制成纤维细胞生长因子通过抑制FGFR1信号.ppt

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Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 海基会抑制成纤维细胞生长因子通过抑制FGFR1信号

Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 Tyrosine Phosphorylation and Subsequent ERK Activation * Authors: Dmitry Kovalenko, Xuehoi Yang, Robert J. Nadeau, Lauren K. Harkins, and Robert Friesel The Journal of Biological Chemistry April 18, 2003 Presentation: Jaymie Krone March 11, 2005 Overview of FGFs and Sef The Big Picture The Questions Q1 Results and Conclusions Q2 Q3 Q4 The Answers Outline Overview of Fibroblast Growth Factors Family of polypeptides with 23 members Regulate: Cell proliferation Migration Differentiation Embryonic pattern formation Overview of Fibroblast Growth Factors Pathway FGF complex binds and FGFRs dimerize ? Autophosphorylation on tyrosine residues (docking sites for SH2 domain) FRS2 binds and is tyrosine-phosphorylated FRS2 binds to SH2 domain on the adaptor protein Grb2 and the protein-tyrosine phosphatase SHP2 Grb2 attracts SOS SOS activates Ras pathway Overview of Fibroblast Growth Factors Previous Studies- FGF signaling: Is essential for cell proliferation and survival in mouse embryo before implantation Is essential for cell migration during gastrulation Has a role in development of brain, limb buds, and lung, as well as many other tissues and organs Overview of Fibroblast Growth Factors Previous Studies: Sprouty family of genes negatively regulate FGF signaling Spry acts between RTKs and Ras/Raf/ERK The FGF synexpression group a group of genes that share a complex expression pattern FGF8, FGF3, Spry, and Sef Overview of Fibroblast Growth Factors Sef Similar expression to FGF genes transmembrane protein whose embryonic expression is similar to other members of the FGF synexpression group expression is regulated by FGF Studies with Zebrafish and Xenopus Sef inhibits FGF signaling Sef co-immunoprecipitates with FGFR1 and FGFR2 The Big Picture FGF signaling The Big Question What inhibits FGF signaling? The Little Picture The Little Question Sef How does Sef in