中西医结合疗糖尿病周围神经病变60例疗效观察.docVIP

中西医结合治疗糖尿病周围神经病变60例疗效观察 【摘要】 　　目的 观察中西医结合治疗糖尿病周围神经病变 (DPN)的临床疗效。方法 将120例患者随机分为对照组和治疗组各60例，对照组予甲钴胺注射液肌肉注射,治疗组在对照组基础上予益气活血通络汤治疗。观察2组临床疗效及神经传导速度变化。结果 治疗组总有效率为71.7%，对照组总有效率为46.7%，2组比较差异有统计学意义(P＜0.05)。治疗组治疗前后运动神经传导速度（MCV）、感觉神经传导速度（SCV）比较差异有统计学意义（Plt;0.01）；对照组治疗前后MCV、SCV比较差异无统计学意义（Pgt;0.05）。2组治疗后MCV、SCV比较差异均有统计学意义(P＜0.05)结论 益气活血通络汤联合甲钴胺注射液治疗糖尿病神经病变有较好疗效。 【关键词】 糖尿病神经病变 汤剂 益气活血 通络 中西医结合疗法 　　【Abstract】 Objective To observe the effect of combination of traditional Chinese medicine and western medicine on the treatment of diabetic peripheral neuropathy (DPN). Methods 120 patients were randomly divided into control group and treatment group. Patients in the control group received mecobalamin intramuscular injection. Patients in the treatment group were treated by Yiqihuoxue Tongluo decoction combined with basis treatment in control group. Clinical effect and changes in nerve conduction velocity were observed in two groups. Results The total effective rate in treatment group (71.7%) was higher than that in control group (46.7%, Plt;0.05). There were significant difference between before and after treatment on motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV, Plt;0.01) in treatment group. In control group before and after treatment there was no significant difference on MNCV and SNCV (Pgt;0.05). Conclusion Combination of traditional Chinese medicine and western medicine has definite effect on the treatment of DPN. 　　【Key words】 Diabetic neuropathy; Decoction; Yiqihuoxue; Tongluo; Combination of TCM with Western medicine 　　糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）是临床常见的糖尿病慢性并发症之一，虽然不是糖尿病致死的主要原因，却是糖尿病患者致残的主要原因，严重影响患者的生存状态。2002-01—2007-12，笔者在饮食控制、降糖药物治疗的基础上，予益气活血通络汤加甲钴胺注射液治疗DPN60例，并与单纯甲钴胺注射液治疗60例对照观察，现报告如下。 　　1 资料与方法 　　1.1 诊断标准［1］ 　　符合世界卫生组织（WHO）1999年糖尿病诊断标准 ,同时符合下列标准 :①肢端感觉异常：有麻木、灼热、冷痛感觉；②神经系统检查腱反射减弱或消失,触觉和温觉降低；③肌电图检查运动和感觉神经传导速度减慢；④排除其他疾病引起的神经病变。 　　1.2 一般资料 　　120例均为我院内科住院患者,随机分为2组。治疗组60例, 男36例,女24例；年龄最大78岁,最小39岁，平均62.3岁；1型糖尿病4例,2型糖尿病56例；糖尿病