ve-cadherin与p120ctn在实验性兔颅内动脉瘤中的表达及其意义-expression and significance of ve - cadherin and p 120 ctn in experimental intracranial aneurysms in rabbits.docxVIP

ABSTRACTObjects:The formation of intracranial aneurysm(IA) was still unclear. In our previous studies, the phosphorylation of VE-Cadherin participated in the progress of formating IA, as well as the translocation of β-catenin into the nucleus of endothelial cells. As a regulating factor of the VE-Cadherin-Catenin compound, p120 catenin(p120ctn) played a critical role in regulating the function of endothelial cells. We designed this study to investigate the hypothesis that VE-Cadherin and p120ctn participate the formation of IA, through building the model of experiment IA in rabbis, and testing